Inhaled steroids in the treatment of patients with bronchial asthma, effect of inhaled steroids on airway inflammation and hyperresponsiveness
Abstract
The anti-inflammatory effect of Russian inhaled steroid budesonide (BENACORT) was studied in 10 patients with mild bronchial asthma. The moderate inflammatory activity in bronchoalveolar spaces proved by increased levels of neutrophiles and eosinophiles in bronchoalveolar lavage (BAL) was observed in all patients. The study had single-blind, crossover, placebo-controlled design.
The tmstwothy improving in functional pulmonary indices, reduction of levels of eosinophiles and neutrophils in BAL, decrease in bronchial inflammatory index, diminution of airway hyperresponsiveness were observed after 2-week treatment with benacort. The results of this study confirmed the significant anti-inflammatory effect of benacort.
About the Authors
O. A. Satochnikova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
M. V. Samsonova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. V. Chemiak
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. L. Chemjaev
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
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Review
For citations:
Satochnikova O.A., Samsonova M.V., Chemiak A.V., Chemjaev A.L. Inhaled steroids in the treatment of patients with bronchial asthma, effect of inhaled steroids on airway inflammation and hyperresponsiveness. PULMONOLOGIYA. 1996;(4):21-28. (In Russ.)
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