Lung surfactant influence on methabolic and functional state of pulmonary cells in rats with bleomycin-induced pneumofibrosis
Abstract
The influence of lung surfactant on E-rosette formation by pulmonary lymphocytes, the activity of secreted interleukin-1 and complex influence of macrophages on fibroblast growth were studied in rats with developing pneumofibrosis was found to loose the ability to decrease E-rosette formation of pulmonary lymphocytes. Cultivation of pulmonary macrophages in the presence of lung surfactant induced an augmentation of the secretion of interleukin-1. Cultivation of skin-muscular fibroblasts in the medium, in which macrophages had been preliminarily incubated, was accompanied by a decrease of 3H-thymidin incorporation in DNA of fibroblasts. Addition of lung surfactant to the medium enhanced this effect. The suppressive effect of surfactant-macrophage system from the lung with developing fibroblasts was the most manifested as compared to control. The more expressive effect of the surfactant from fibrotic lung on fibroblast growth was found to be a prostaglfndin-dependent process.
About the Authors
A. D. TaganovichBelarus
V. K. Kuhta
Belarus
I. V. Sacharenko
Belarus
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Review
For citations:
Taganovich A.D., Kuhta V.K., Sacharenko I.V. Lung surfactant influence on methabolic and functional state of pulmonary cells in rats with bleomycin-induced pneumofibrosis. PULMONOLOGIYA. 1996;(2):57-63. (In Russ.)