NEW DIAGNOSTIC OPPORTUNITIES OF LUNG DIFFUSION CAPACITY MEASUREMENT FOR CO AND NO
https://doi.org/10.18093/0869-0189-2011-0-1-85-88
Abstract
Summary. When using the initial CO concentration of 0.3 % in the test gas, a significant deficit of Hb has been occurred as a result of carboxyhemoglobin (COHb) generation. Therefore, the pulmonary capillary haemodynamics (blood flow – FC) should be taken into account. The aim of this study was to reveal relationships between measured values of membrane diffusion capacity (DM), the total diffusion lung capacity for CO (DLCO) and computerized values of VC and FC considering COHb generation. According to the equation derived mean relative flow concentration of COHb in CO= 0.3 % were ≥ 10 % in healthy and in patients with pulmonary artery hypertension (PAH), but VC and FC were about twice lower in PAH patients. We have shown that simultaneous measurements of DM and DLCO in two different CO values allows calculate FC in spite of VC and could be used for noninvasive investigation of pulmonary haemodynamics.
About the Authors
E. V. Babarskov
ФГУ "НИИ пульмонологии ФМБА России"
Russian Federation
Russian Federation
к. т. н., ведущий научный сотрудник лаборатории функциональных и ультразвуковых методов исследования
105077, Москва, ул. 116я Парковая, 32, к. 4
тел.: (495) 465-52-64
Yu. A. Shulagin
ГНЦ "Институт медико6биологических проблем РАН"
Russian Federation
Russian Federation
к. б. н., ведущий научный сотрудник
123007, Москва, Хорошевское ш., 76а
тел.: (499) 195-67-46
Han Do O
ФГУ "НИИ пульмонологии ФМБА России"
Russian Federation
Russian Federation
к. м. н., зав. отделом биоэнергетики
105077, Москва, ул. 116я Парковая, 32, к. 4
тел.: 8 (916) 407-10-99
A. V. Chernyak
ФГУ "НИИ пульмонологии ФМБА России"
Russian Federation
Russian Federation
к. м. н., зав. лабораторией функциональных и ультразвуковых методов исследования
105077, Москва, ул. 116я Парковая, 32, к. 4
тел.: (495) 465-53-84
S. R. Aisanov
ФГУ "НИИ пульмонологии ФМБА России"
Russian Federation
Russian Federation
к. м. н., зав. лабораторией функциональных и ультразвуковых методов исследования
105077, Москва, ул. 116я Парковая, 32, к. 4
тел.: (495) 465-53-84
A. G. Chuchalin
ФГУ "НИИ пульмонологии ФМБА России"
Russian Federation
Russian Federation
акад. РАМН, д. м. н., проф., директор
105077, Москва, ул. 116я Парковая, 32, к. 4
тел.: (495) 465-52-64
References
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Review
For citations:
Babarskov E.V., Shulagin Yu.A., O H.D., Chernyak A.V., Aisanov S.R., Chuchalin A.G. NEW DIAGNOSTIC OPPORTUNITIES OF LUNG DIFFUSION CAPACITY MEASUREMENT FOR CO AND NO. PULMONOLOGIYA. 2011;(1):85-88. (In Russ.) https://doi.org/10.18093/0869-0189-2011-0-1-85-88
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