Nadphn-diaphorase activity of the respiratory epithelium during bronchial asthma
Abstract
The activity and topochemistry of the NADPHN-diaphorase co-localized with NO-syntase were studied for the surgical material taken after lung resection of patients suffering from bronchoal asthma. An uneveness of the morphological indicators has been determined for the respiratory tracts’ membranous wall remodelling. This uneveness has specified different intensity of the epithelium’ NADPHN-diaphorase reaction. Enzyme moderate activity in small and medium bronchi prevailed for mild persisting bronchial asthma. The both number of small and medium bronchi with the increased NO-syntase and its level grew with the disease severity. In parallel the number of the bronchi with the reduced enzyme expression increased. This is probably due to the development of irreversable obstruction signes. The high level of the enzyme was also revealed in the cells being the inflammation residents (alveolar macrophages and tissue basophile) and the cells type in the alvelotsitakh during a severe bronchial asthma
About the Authors
V. A. Nevzorova
Кафедра гистологии, кафедра пропедевтики внутренних болезней Владивостокского медицинского университета
Russian Federation
Russian Federation
M. Yu. Protopopova
Кафедра гистологии, кафедра пропедевтики внутренних болезней Владивостокского медицинского университета
Russian Federation
Russian Federation
E. V. Eliseeva
Кафедра гистологии, кафедра пропедевтики внутренних болезней Владивостокского медицинского университета
Russian Federation
Russian Federation
V. F. Baranov
Кафедра гистологии, кафедра пропедевтики внутренних болезней Владивостокского медицинского университета
Russian Federation
Russian Federation
B. I. Geltser
Кафедра гистологии, кафедра пропедевтики внутренних болезней Владивостокского медицинского университета
Russian Federation
Russian Federation
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Review
For citations:
Nevzorova V.A., Protopopova M.Yu., Eliseeva E.V., Baranov V.F., Geltser B.I. Nadphn-diaphorase activity of the respiratory epithelium during bronchial asthma. PULMONOLOGIYA. 1997;(2):68-71. (In Russ.)
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