Changes in eosinophile properties due to the influence of serum of the patients with bronchial asthma
Abstract
A rosette-forming ability of the blood eosinophiles was studied for six patients with the bronchial asthma and four healthy donors. The number of low density eosinophiles was for certain higher for the sick people in contrast to the healthy ones. However the number of high density eosinophiles differed negligibly. Incubation of healthy people’s eosinophiles with the beta-andrenoblocker obsidan almost doubled the number of rosettes with the sheep’s erythrocytes. At the same time donors’ eosinophile incubation with the blood serum of patients with the bronchial asthma, increased their rosette formation almost six times. Preliminary serum inactivation by heating completely deprived it of the ability to stimulate rosette formation for donors’ eosinophiles.
About the Authors
A. B. Berestetsky
АОЗТ МТФ “Авиценна”;
МО “ Новая больница”
Russian Federation
Russian Federation
I. V. Leshchenko
АОЗТ МТФ “Авиценна”;
МО “ Новая больница”
Russian Federation
Russian Federation
I. A. Kardashina
АОЗТ МТФ “Авиценна”;
МО “ Новая больница”
Russian Federation
Russian Federation
References
1. Basran G.S., Ball A.J., Hanson J.M. et al. Circulating beta-adrenoceptor blocking factors in asthma / / Eur. J. Respir. Dis.— 1984.— Suppl.135.— P.226—230.
2. Barnes P.J. The changing face of asthma / / Quart. J. Med.— 1987.— Vol.63.— P.359—365.
3. Capron M ., Jonault T. IgE receptors of human eosinophils and eosinophil heterogenity / / Ann. Immunol.— 1986.— Vol. 137.— P.371—374.
4. Dahl R., Venge P. Role of the eosinophils in bronchial asthma / / Eur. J. Respir. Dis.— 1982.— Suppl.122.— P.23—28.
5. Fukuda Т., Dunnette S.L., Reed C.E. et al. Increased number of hypodense eosinophils in the blood of patients with bronchial asthma / / Am. Rev. Respir. Dis.— 1985.— Vol. 132.— P.981—985.
6. Fukuda Т., Gleich G.J. Heterogenity of human eosinophils / / J. Allergy Clin. Immunol.— 1989.— Vol.83.— P.369—373.
7. Frigas E., Gleich G.J. The eosinophil and the pathophysiology of asthma / / J. Allergy Clin. Immunol.— 1986.— Vol.77.— P.527—537.
8. Gleich G.J. The functions of eosinophils / / Ann. Immunol.— 1986.— Vol.l37D.— P.136—141.
9. Gleich G.J., Loegering D.A., Adolphson C.R. Eosinophils and bronchial inflammation / / Chest.— 1985.— Vol.87, № 1.— Suppl.— P.10S—13S.
10. Hakansson L., Carlson M., Stalenheim G. et al. Migratory responses of eosinophil and neutrophil granulocytes from patients with asthma / / J. Allergy Clin. Immunol.— 1990.— Vol.85.— P.743.
11. Hakansson L., Rak S., Dahl R. et al. The formation of eosinophil and neutrophil chemotactic activity during a pollen season and after allergen challenge / / Ibid.— 1989.— Vol.83.— P.933—938.
12. Jondal М. ( Джондал М. ) Использование теста розеткообразования с эритроцитами барана в качестве маркера человеческих Т-лимфоцитов / / Лимфоциты: выделение, фракционирование и характеристика / Под ред. Дж.Б.Натвига, П.Перлманна, Х.Вигзелля: Пер. с англ.— М.: Медицина, 1980.— С.57.
13. Kay A.B. Inflammatory cells in acute and chronical asthma / / Am. Rev. Respir. Dis.— 1987.— Vol.135.— P.S63—S66.
14. Kay A.B. Eosinophils as effector cells in immunity and hypersensitivity disorders / / Clin. Exp. Immunol.— 1985.— Vol.62.— P.l — 12.
15. Meurs H., Koeter G.H., de Vries K., Kauffman H.F. Dynamics of lymphocyte beta-adrenoreceptor system in patients with allergic bronchial asthma / / Eur. J. Respir. Dis.— 1984.— Suppl.135.— P.47—61.
16. Sheller J.R. Review: Asthma: emerging concepts and potential therapies / / Am. J. Med. Sei.— 1987.— Vol.293.— P.298—303.
17. Spry C.J.F. New properties and roles for eosinophils in disease: discussion paper / / J. Roy. Soc. Med.— 1985.— Vol.78.— P.844—848.
18. Sedgvick J.B., Frick W.E., Soudel P.M. et al. The appearence of hypodense eosinophils during interleukin-2 treatment / / J. Allergy Clin. Immunol.— 1990.— Vol.85.— P.557—566.
19. Sokol R.J., James N.T., Wales J. et al. Morphometry of eosinophils in human blood / /A cta Anat.— 1987.— Vol.129.— P.211—213.
20. Sorice F., De Sim one С. Human eosinophil heterogenity / / Ric. Clin. Lab.— 1986.— Vol. 16.— P.429—434.
21. Wardlaw A.J., Kay A.B. The role of /he eosinophil in the pathogenesis of asthma / / Allergy.— 1987.— Vol.42.— P.321—326.
22. Weller P.F. Eosinophilia / / J. Allergy Clin. Immunol.— 1984.— Vol.73.— P.l — 10.
23. Weller P.F., Goetzl E.J. The human eosinophil roles in host defense and tissue injury / / Am. J. Pathol.— 1980.— Vol.100.— P.790—820.
Review
For citations:
Berestetsky A.B., Leshchenko I.V., Kardashina I.A. Changes in eosinophile properties due to the influence of serum of the patients with bronchial asthma. PULMONOLOGIYA. 1997;(2):57-60. (In Russ.)
Views:
144
Email this article 