Effect of budesonide on late asthmatic responce and associated increase of airway hyperresponsiveness in allergen inhalation test
Abstract
We determined whether inhaled budesonide (600mcg) had given by Cyclohaler (Pulmomed) before allergen inhalation challenge (AC) inhibited the late asthmatic responce (LAR) and subsequent bronchial hyperpesponsiveness to histamine (BR). Five asthmatics sensitized to Dermatophagoides pteronyssinus (Prick-test), who had previously shown the development of early and late asthmatic responce to AC with Dermatophagoides pteronyssinus, were studied in a double-blind placebo-controlled randomised protocol.
Budesonide significantly reduced the LAR induced by Dermatophagoides pteronyssinus (maximum % fall of FEV1: -16.0±6.1% with budesonide versus -26.2±5.5% with placebo; p<0.01) and inhibited the increase of BR (decrease of logPC20 by 1.43±0.69 mg/ml with budesonide versus 4.11±0.83 mg/ml with placebo, p<0.05).
Our data suggest that budesonide reduces the LAR and protects airways against increased BR after AC.
About the Authors
N. A. Boloshina
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. V. Cherniak
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
T. L. Pashkova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. S. Sokolov
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
M. V. Samsonova
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии М3 РФ
Russian Federation
Russian Federation
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Review
For citations:
Boloshina N.A., Cherniak A.V., Pashkova T.L., Sokolov A.S., Samsonova M.V., Chuchalin A.G. Effect of budesonide on late asthmatic responce and associated increase of airway hyperresponsiveness in allergen inhalation test. PULMONOLOGIYA. 1999;(1):50-53. (In Russ.)
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