Peculiarities of erythrocytes cytoskeleton in bronchial asthma

Abstract

The aim of this study was to reveal the peculiarities of erythrocytes skeleton content in bronchial asthma (BA) patients under the modulation of adrenergic agents. The cytoskeleton was studied in 5 healthy men and 13 patients with BA by modified Chentsov’se ta l. method (1982). The integral optic density was evaluated by imagining analyser of “Ista-Videotesf firm (Saint-Petersburg city). It was found that cytoskeleton proteins were decreased (in BA especially in endogenous BA (enBA). The cytoskeleton proteins were decreased under the adrenalin influence in healthy men, in exogenous BA (exBA) and in enBA but they were increased under the β-adernoblokers influence (Obsidan) in the same group except exBA which was characterized by the decreased cytoskeleton content. The data obtained indicates cytoskeleton’s peculiarities depending on BA variants and on a close relation between the erythrocytes adernoreactive system and the cytoskeleton as well.