Peculiarities of pulmonary ventilation, haemoreology and haemodynamics in patients with chronic obstructive lung disease in combination with ischaemic heart disease

Abstract

The objective of the research was to study the peculiarities of external breathing, haemoreology, heart and lung haemodynamics in patients with mixed pathology depending on the predominance of chronic obstructive lung  disease (COLD) and ischaemic heart disease (IHD). Eighty-eight patients inspected were separated into two groupsaccording to the leading nosology in the clinical picture. The patients with leading COLD had the obstructive type of ventilatory failure, accompanied by severe hypoxemia and hypercapnia, formation of lung arterial hypertension, against which background diastolic dysfunction of both ventricles and the reduction in systolic function of the right ventricle are developing.
The peculiarity of clinical and functional conditions of patients with leading IHD was the syndrome of blood hyperviscosity, accompanied by diastolic and systolic ventricular dysfunction, formation of moderate lung  hypertension and disorder in blood gas composition. The combination of the obstructive ventilatory failure, lungarterial hypertension and blood hyperviscosity was typical for COLD and IHD patients and caused the failure of systolic and diastolic function of the both of cardiac parts which must be considered in choosing the therapeutic treatment for this kind of patients.