Clinicaland-morphological peculiarities of acute pneumonia in infants with primary immune deficiency

Abstract

This article displays results of clinical and morphological comparison of acute pneumonia (AP) in 32 infants with signs of primary immune deficiency (PID). Etiology AP and a form of PID were recognized by means of a complex of immunological testing during the patients’ lifetime and post-mortem immunohistochemical, histobacterioscopic, and bacteriological examinations. Principal distinguishing features of AC under PID background were: 1) mixed etiology of the disease, in which viral-and-bacterial-and-mycotic associations acquire the great importance; 2) a significant extension of lung tissue injury with predominance of an alternative component of inflammation; 3) a tendency of infectious and inflammatory lung processes to generalization.