Morphological evaluation of bronchial mucosa in various forms of bronchial asthma
Abstract
The aim of the study was morphological evaluation of bronchial mucosa in exacerbation of various bronchial asthma forms. Seventy seven bronchial asthma patients aged 15 to 68 years underwent bronchoscopy with endobronchial biopsy, and quantitative analysis of cell compound of the obtained material was performed. There were no a significant difference in the basal membrane thickness, number of histiocytes, macrophages and plasmocytes in the stroma cell infiltrate between various forms, of bronchial asthma. Interepithelial lymphocyte and eosinophil number was considerably more in atopic asthma as well as high cell density of the infiltrate and more eosinophils, lymphocytes and fibroblasts and less neutrophils in it. The combined form of bronchial asthma differed from the atopic one by less eosinophil and more neutrophil amount in the stroma. The only difference between the infectious asthma and the combined asthma was the eosinophil number in the stroma that was significantly higher in the combined asthma. So, the eosinophil account in 1 mm2 of the stroma became the only parameter which differed reliably between all the forms of bronchial asthma.
About the Authors
L. I. Volkova
Кафедра внутренних болезней педиатрического факультета Сибирского государственного медицинского университета
Russian Federation
Russian Federation
A. A. Budkova
Кафедра внутренних болезней педиатрического факультета Сибирского государственного медицинского университета
Russian Federation
Russian Federation
S. R. Budkov
Кафедра внутренних болезней педиатрического факультета Сибирского государственного медицинского университета
Russian Federation
Russian Federation
V. S. Bogomyagkov
Кафедра внутренних болезней педиатрического факультета Сибирского государственного медицинского университета
Russian Federation
Russian Federation
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Review
For citations:
Volkova L.I., Budkova A.A., Budkov S.R., Bogomyagkov V.S. Morphological evaluation of bronchial mucosa in various forms of bronchial asthma. PULMONOLOGIYA. 2002;(5):68-72. (In Russ.)
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