Correction of phagocytes’ function in patients with acute abscess and gangrene of the lung

Abstract

Patients with the lung abscess and gangrene demonstrate quantitative disproportion of the polymorphnonuclear and mononuclear phagocytes and disorders in their oxygen-dependent metabolic, procoagulant and proteolytic activities in BAL fluid from the injured lung. The phagocytes’ reaction to activators and inhibitors can be different depending on the initial status of these cells. The correction of the phagocytes’ function requires a prior assessment of the changes in the leukocytes’ metabolic activity provided by activators and inhibitors. Sometimes the correction could be performed by extracorporal methods only followed by transposition of autologous mononuclear phagocytes into the injured lung.