Comparative efficacy of different preventing medication modes in post-exercise bronchoconstriction in children: multi-center randomized study results
Abstract
The article demonstrates results of multi-center randomized placebo-controlled study of efficacy of 4 drug modes of post-exercise bronchoconstriction prevention in asthmatic children who received long-term therapy with inhaled corticosteriods. The combination of fluticazone propionate and salmeterol (Seretid 50/100) was found to be beneficial and reasonable as the first-line therapy. An increase of the inhaled corticosteroid’s dose in asthmatic children with post-exercise bronchoconstriction is reasonable if its combination with the long-acting β2-agonist does not permit to achieve a sufficient bronchoprotective effect.
About the Authors
I. V. Smolenov
Государственная медицинская академия
Russian Federation
Russian Federation
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
S. A. Stakhanova
Государственная медицинская академия
Russian Federation
Russian Federation
Yu. A. Petrovskaya
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
N. A. Ivanova
Военно-медицинская академия
Russian Federation
Russian Federation
N. G. Mashukova
Ангарский астма-центр
Russian Federation
Russian Federation
V. R. Lipina
Городская детская больница № 9
Russian Federation
Russian Federation
N. A. Smirnov
Государственная медицинская академия
Russian Federation
Russian Federation
Yu. Yu. Zima
Государственная медицинская академия
Russian Federation
Russian Federation
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Review
For citations:
Smolenov I.V., Ogorodova L.M., Stakhanova S.A., Petrovskaya Yu.A., Ivanova N.A., Mashukova N.G., Lipina V.R., Smirnov N.A., Zima Yu.Yu. Comparative efficacy of different preventing medication modes in post-exercise bronchoconstriction in children: multi-center randomized study results. PULMONOLOGIYA. 2002;(2):50-57. (In Russ.)
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