Gene polymorphism of xenobiotics transformation enzymes and childhood bronchial asthma peculiarities
Abstract
An association was investigated between clinical sighs of child’s asthma with gene isoleucine/valine polymorphism of cytochrome P-4501A1 (CYP1A1 lle/Val), null-polymorphism of glutatione-S-transferase M1 (GSTM1”-”), phenotypic N-acetyltransferase (rapid and slow acetylators — RA and SA) and CYP1A (rapid, intermediate and slow metabolizers of theophylline — RM, IM and SM) polymorphism and passive smoking (/7=100). Polyvalent allergy In non-smokers (/7=40) was associated with SA (odds ratio (ОЯ)=1.63; Ci: 0.27-11.87) and normal GSTM1 genotype (OR=3.73; Cl: 0.38-10.73). Early occurrence of asthma was associated with SA (ОЯ=2.48; Cl: 0.45-17.25). Severe asthma course correlated with CYP1A1 lle/Val genotype (OR=2.75; Cl: 0.27-36.24) and SA (ОЯ=1.9; Cl: 0.38-10.73). Smoking modified the functional significance of the polymorph traits. GSTM1 -genotype and SM-phenotype in passive smokers (л=60) were associated with these clinical features of asthma: OR for GSTM1 genotype was 1.98; Cl: 0.46-9.95); 9.0 (Cl: 1.07-409.9); 1.23 (0.36-4.27) for polyvalent allergy, early asthma occurrence and severe course respectively. The values for SM-phenotype were 1.7 (Cl: 0.28-9.25); 2.6 (Cl: 0.29-22.31) and 2.88 (Cl: 0.57-14.24) respectively.
About the Authors
V. V. Lyakhovich
Институт молекулярной биологии и биофизики СО РАМН
Russian Federation
Russian Federation
S. M. Gavalov
кафедра педиатрии ФУВ Новосибирской государственной медицинской академии
Russian Federation
Russian Federation
V. A. Vavilin
Институт молекулярной биологии и биофизики СО РАМН
Russian Federation
Russian Federation
O. A. Ryabova
кафедра педиатрии ФУВ Новосибирской государственной медицинской академии
Russian Federation
Russian Federation
S. I. Makarova
Институт молекулярной биологии и биофизики СО РАМН
Russian Federation
Russian Federation
N. I. Gutkina
Институт молекулярной биологии и биофизики СО РАМН
Russian Federation
Russian Federation
O. B. Chasovnikova
Институт молекулярной биологии и биофизики СО РАМН
Russian Federation
Russian Federation
O. V. Suslyakova
Институт молекулярной биологии и биофизики СО РАМН
Russian Federation
Russian Federation
A. V. Likhanov
кафедра педиатрии ФУВ Новосибирской государственной медицинской академии
Russian Federation
Russian Federation
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Review
For citations:
Lyakhovich V.V., Gavalov S.M., Vavilin V.A., Ryabova O.A., Makarova S.I., Gutkina N.I., Chasovnikova O.B., Suslyakova O.V., Likhanov A.V. Gene polymorphism of xenobiotics transformation enzymes and childhood bronchial asthma peculiarities. PULMONOLOGIYA. 2002;(2):31-38. (In Russ.)
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