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A role of genetic factors for bronchial asthma occurrence in children

Abstract

We assessed a contribution of genetic factors to the bronchial asthma development in children basing on the genealogy analysis of 302 asthmatic children. It was dem onstrated that the inherited factors play the principal role in the disease occurrence providing by the additive action of polygens.
The genetic predisposing markers of bronchial asthma were revealed in Russian children (alleles HLA DRB1 ) and their distribution was investigated in the families burdened by the disease. This information could be used to form the high-risk groups for the bronchial asthma development and to predict its occurrence in the families.

About the Author

A. E. Bogorad
Московский научно-исследовательский институт педиатрии и детской хирургии Минздрава РФ
Russian Federation


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Bogorad A.E. A role of genetic factors for bronchial asthma occurrence in children. PULMONOLOGIYA. 2002;(1):47-56. (In Russ.)

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