The rational application of antibiotics on the basis of their pharmacokinetics in infants with pneumo

Abstract

Study results of pharmacokinetics of Sizomycine and Amikacin aminoglycozyde antibiotics in infants with severe pneumonia have been shown. It was revealed that the pharmacokinetics of these drugs depends on the patients’ condition severity. A significant individual variability of the antibiotics’ pharmacokinetics was found that requires their individual dosage. The pharmacokinetic variability is due to "patient’s factors". A multiple correlation analysis demonstrated quantitative relationships between pharmacokinetic parameters and such the "patient’s factors" as body weight, leukocytes amount, red blood cells sedimentation rate, hematocrit, creatinine and urea serum concentrations, oxygen and carbon dioxide blood partial pressures. An individual prediction of pharmacokinetic parameters, e.g. a total clearance of creatinine according to the "patient’s factors" is the basis for the initial calculation of the antibiotic individual dose when it is important to determine the optimal dose quickly.