Cystic fibrosis in adult patients: cardiac and respiratory function
Abstract
Aim: To assess the state of cardiac and respiratory function in adult cystic fibrosis patients. 36 patients participated in the study. Lung function tests and Doppler echocardiography were performed to each patient. The majority of adult CF patients develop generalized obstructive pattern of lung function and hyperinflation. Significant decrease of VC and its part in TLC was noted. Assessment of exercise tolerance revealed significant decrease of hemoglobin oxygen saturation and heart rate increase. Right atrium and ventricle dilatation and an increase of systolic pressure in pulmonary artery were reported in 20% of patients, all of them had severe bronchial obstruction (FEV1 <35% pred), in 28% of patients left ventricle dysfunction of both systolic and diastolic nature was registered.
Our finding suggest that generalized obstructive disorders, hyperinflation and reduction in diffusion capacity are characteristic for adult cystic fibrosis patients. Pulmonary hypertension and cor pulmonale develop in patients with severe obstructive disorders.
About the Authors
J. K. Naumenko
НИИ пульмонологии М3
Russian Federation
Russian Federation
A. V. Cherniak
НИИ пульмонологии М3
Russian Federation
Russian Federation
E. L. Amelina
НИИ пульмонологии М3
Russian Federation
Russian Federation
G. V. Nekludova
НИИ пульмонологии М3
Russian Federation
Russian Federation
E. N. Kalmanova
НИИ пульмонологии М3
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии М3
Russian Federation
Russian Federation
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Review
For citations:
Naumenko J.K., Cherniak A.V., Amelina E.L., Nekludova G.V., Kalmanova E.N., Chuchalin A.G. Cystic fibrosis in adult patients: cardiac and respiratory function. PULMONOLOGIYA. 2001;(4):28-33. (In Russ.)
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