Lung carcinoma in persons lived for long time at radioactive contaminated territories of Semipalatinsk region (Kazakhstan)
Abstract
The aim of this work was to study morphological peculiarities and expression of biomolecular tumor markers including IGF family members in lung carcinoma patients lived for long time at Semipalatinsk territories with radioactive contamination.
The investigation drew operated and biopsy materials of 27 lung cancer patients; among them 17 patients (the 1-st group) lived from their childhood to 1993 near the proving ground and experienced radiation for long time (the annual irradiation dose exceeded 0.1 ber). The comparative group involved 10 patients (the 2-nd group) lived at Kazakhstan territories with normal radiation level. There were 23 males and 4 females aged from 45 to 69 years among the patients. Metastases were found in 5 of 17 lung carcinomas occurred under radiation exposure and in 7 of 10 lung carcinoma patients from areas with normal radiation level. The tumors had various histological types according to the WHO characterization. We used paraffin embedded archive blorks from Semipalatinsk oncology center. The sections were stained by hemotoxyllin and eosin, alcian blue, and by the van Gieson staining.
To detect the tumor histogenesis we used electronic microscopy of paraffin blocks and semi-thin sections stained by methylene bine, azur II, fuxine.
We performed immunohistochemical examination using immune peroxidase method, mono- and polyclonal antibodies against chromogranin, IGFI, IGFII, IGFBP1-6.
The characteristic features of lung carcinomas in residents at the radioactive contaminated territories of Semipalatinsk region (Kazakhstan) were constant presence of dust particles in tumors of various histological types and from different sites.
Lung carcinomas at the Semipalatinsk region have histogenetic peculiarities and they can be characterized as neuroendocrine tumors, not only small cell type but also non-small cell type with neuroendocrine differentiation.
The investigated lung carcinomas have specific mechanisms for tumor growth regulation referred to IGF family with high activity of IGF II and IGFBP1, 2 compared to the 2-nd group.
About the Authors
E. A. Kogan
ММА им. И.М. Сеченова
Russian Federation
Russian Federation
G. S. Sagindikova
ММА им. И.М. Сеченова
Russian Federation
Russian Federation
S. M. Sekamova
ММА им. И.М. Сеченова
Russian Federation
Russian Federation
G. Jak
Университет Филиппса
Germany
Germany
L. Sh. Redzhabaeva
Областное патолого-анатомичсское бюро
Kazakhstan
Kazakhstan
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Review
For citations:
Kogan E.A., Sagindikova G.S., Sekamova S.M., Jak G., Redzhabaeva L.Sh. Lung carcinoma in persons lived for long time at radioactive contaminated territories of Semipalatinsk region (Kazakhstan). PULMONOLOGIYA. 2001;(4):23-28. (In Russ.)
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