Microbiological aspects of etiology and antimicrobial therapy of bronchopulmonary infection in cystic fibrosis adults
Abstract
We studed microbiology contamination of bronchial sputum in the 68 sample and other parameters (infectivity, constancy, ecological likeness of bacterias) in 21 adult patients with cystic fibrosis (CF) exaserbation. There were P.aeruginosa, St.aureus and Candida spp. as more often cultures. P.aeruginosa and St.aureus sensitiveness was investigated and we consider that empiric antimicrobial therapy adults patients with exacerbation of CF should consist (include): meropenem (or ceftasidi + netylmicin) + vancomycinum (or rifampicinum) ± fluconasol.
About the Authors
М. N. Zubkov
НИИ пульмонологии М3
Russian Federation
Russian Federation
V. A. Samoylenko
НИИ пульмонологии М3
Russian Federation
Russian Federation
E. N. Gugunidze
НИИ пульмонологии М3
Russian Federation
Russian Federation
A. G. Shushalin
НИИ пульмонологии М3
Russian Federation
Russian Federation
References
1. Зубков М.H., Меньшиков Д.Д., Гугуцидзе Е.Н. и др. Микробиологическая диагностика смешанных анаэробно-аэробных инфекций в хирургии. Антибиотики и химиотер. 1995; 2: 46—50.
2. Fahy i.V., Keoghan М.Т., Crummy E.J., Fitzgerald М.Х. Васteraemia and fungaemia in adults with cystic fibrosis. J. Infect. 1991; 22: 241—245.
3. FitzSimmons S.C. The changing epidemiology of cystic fibrosis. J. Pediatr. 1993; 122: 1—9.
4. Govan J.R.W., Brown P.H., Maddison J. et at. Evidence for transmission of Pseudomonas cepacia by social contact in cystic fibrosis. Lancet 1993; 342: 15—19.
5. Hodson M.E., Geddes D.M. Cystic fibrosis. London: Chapman; 1995.
6. Hoiby N., Doring G., Schiotz P.O. Pathogenic mechanisms of chronic P.aeruginosa infection in cystic fiboris patients. Antibiot. Chemother. 1987; 39: 69—76.
7. Pedersen S.S. Prevention early treatment of Pseudomonas aeruginosa infection. Copenhagen: Righospitalet; 1992.
8. Schwab U.E., Wald A.E., Carson J.L. et al. Increased adherence of Staphylococcus aureus from cystic fibrosis lungs to airway epithelial cells. Am. Rev. Respir. Dis. 1993; 148: 365—369.
Review
For citations:
Zubkov М.N., Samoylenko V.A., Gugunidze E.N., Shushalin A.G. Microbiological aspects of etiology and antimicrobial therapy of bronchopulmonary infection in cystic fibrosis adults. PULMONOLOGIYA. 2001;(3):38-41. (In Russ.)
Views:
202
Email this article 