Spectrum of local drug resistance of Mycobacterium tuberculosis in penitentiary healthcare facilities

Abstract

Summary. A local spectrum of Mycobacterium tuberculosis drug resistance in penitentiary healthcare facilities at Kirov region has been studied. Drug resistance was found in 84.7 % of patients; the drug resistance to one anti-TB drug was found in 1.9 %, multiple drug resistance (MDR) was found in 9.3 % and multiple wide-spectrum drug resistance (MDR + XDR) was found in 73.6 % of cases. The resistance to most common anti-TB drugs was as follows: to isoniazid 82.9 %, to rifampicin 74.5 %, to ethambutol 76.9 %, and to streptomycin 72.2 %. MDR to first-line and second-line antiTB drugs was as high as 50.9 %. MDR to the most common anti-TB combination (isoniazid + rifampicin + ethambutol + streptomycin + ethionamide (protionamid)) was 13.4 %. Therefore, the chemotherapeutic regimens used the principal anti-TB drugs are expected no to be very effective in most patients treated in penitentiary healthcare facilities; their administration could induce further drug resistance of M. tuberculosis.