Natural history of experimental dust bronchitis

Abstract

The study performed allowed to reproduce experimentally the dust bronchitis and to show a dynamic development of the pathological process in the lungs. After intratracheal insufflation of fine-dispersed inorganic dust there was a certain morphological dynamics in the lungs. Destructive changes of bronchi, bronchiole and bronchopheumonia were observed at an early stage. A productive macrophage reaction developed at the 7th day with the granuloma formation linked topographically with the dust deposition. When the experience period lengthened up to 14 days, granulomatous process grew, exudative and destructive processes calmed down; a tendency to peribronchial and perivascular sclerosis appeared. At a later stage (12 months) the lungs eliminated the dust, the granulomas amount diminished, the peribronchial and perivascular sclerosis spreaded, and centriacinar emphysema developed.