An influence of the local immune corrector IRS 19 with vaccine properties on hydrogen peroxide concentration and myeloperoxidase activity in nasal washes from chronic bronchitis patients
Abstract
Twenty eight adults of both genders with chronic bronchitis participated in the open trial studying the influence of the local immune modulating drug IRS 19 with vaccine properties on polymorphonuclear leukocytes number, H202 concentration and myeloperoxidase activity in nasal washes. The polymorphonuclear leukocytes number increased from 4460±3960 to 10490±10950 cells per ml (p<0.02) after two months of IRS 19 use. This effect accompanied by the myeloperoxidase activity and the H202 concentration increase in 2.6 and 1.4 times, correspondingly (p<0.001). As the "polymorphonuclear leukocytes and myeloperoxidase – H202 – Clˉ " system is the first-line defence against pathogenic microorganisms, the changes mentioned above are likely to be one of the mechanisms enhancing the airways antibacterial immunity in response to the IRS 19 therapy.
About the Authors
Dariusz Nowak
Медицинский институт Лодзинского университета
Poland
Poland
отделение пульмонологии и аллергологии
Michal Prozynski
Лаборатория Института туберкулеза и легочных болезней по изучению бронхов
Russian Federation
Russian Federation
Tadeusch Pietras
Медицинский институт Лодзинского университета
Poland
Poland
отделение пульмонологии и аллергологии
Robert Stolarek
Медицинский институт Лодзинского университета
Poland
Poland
отделение пульмонологии и аллергологии
Piotr Mazerant
Медицинский институт Лодзинского университета
Poland
Poland
Michal Leder
Медицинский институт Лодзинского университета
Poland
Poland
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Review
For citations:
Nowak D., Prozynski M., Pietras T., Stolarek R., Mazerant P., Leder M. An influence of the local immune corrector IRS 19 with vaccine properties on hydrogen peroxide concentration and myeloperoxidase activity in nasal washes from chronic bronchitis patients. PULMONOLOGIYA. 2001;(1):60-65. (In Russ.)
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