pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLCpulmo-2774Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESДействие местного иммунокорректора со свойствами вакцины НРС 19 на концентрацию перекиси водорода и активность миелопероксидазы в смывах из полости носа у больных с хроническим бронхитомAn influence of the local immune corrector IRS 19 with vaccine properties on hydrogen peroxide concentration and myeloperoxidase activity in nasal washes from chronic bronchitis patientsNowakD.NowakDariusz

отделение пульмонологии и аллергологии

отделение пульмонологии и аллергологии

ProzynskiM.ProzynskiMichalPietrasT.PietrasTadeusch

отделение пульмонологии и аллергологии

отделение пульмонологии и аллергологии

StoIarekR.StolarekRobert

отделение пульмонологии и аллергологии

отделение пульмонологии и аллергологии

MazerantP.MazerantPiotr

студент 

г. Лодзь

LederM.LederMichal

студент 

г. Лодзь

Медицинский институт Лодзинского университетаПольшаМедицинский институт Лодзинского университетаPolandЛаборатория Института туберкулеза и легочных болезней по изучению бронховРоссияЛаборатория Института туберкулеза и легочных болезней по изучению бронховRussian Federation200130032001016065Copyright © Nowak D., Prozynski M., Pietras T., StoIarek R., Mazerant P., Leder M., 20012001Nowak D., Prozynski M., Pietras T., StoIarek R., Mazerant P., Leder M.Nowak D., Prozynski M., Pietras T., Stolarek R., Mazerant P., Leder M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/2774

Двадцать восемь взрослых больных обоего пола, страдающие хроническим бронхитом, приняли участие в открытом исследовании, посвященном изучению эффекта применения местного иммуномодулирующего препарата со свойствами вакцины ИРС 19 на число полиморфноядерных лейкоцитов (ПМЯЛ), концентрацию Н202 и активность миелопероксидазы (МЛП) в смывах из полости носа. Число ПМЯЛ, выделявшихся из полости носа, увеличилось после двух месяцев применения ИРС 19 с 4460±3960 до 10 490±10 950 клеток на мл (р<0,02). Этот эффект сопровождался повышением активности МЛП и концентрации Н202, соответственно, в 2,6 и 1,4 раза (р<0,001). Поскольку система ПМЯЛ и МЛП – Н202 – CIˉ находится на переднем крае защиты от проникновения патогенных микроорганизмов, можно предположить, что упомянутые выше изменения могут представлять собой один из механизмов, приводящих к повышению антибактериального иммунитета в области дыхательных путей в ответ на лечение препаратом ИРС 19.

Twenty eight adults of both genders with chronic bronchitis participated in the open trial studying the influence of the local immune modulating drug IRS 19 with vaccine properties on polymorphonuclear leukocytes number, H202 concentration and myeloperoxidase activity in nasal washes. The polymorphonuclear leukocytes number increased from 4460±3960 to 10490±10950 cells per ml (p<0.02) after two months of IRS 19 use. This effect accompanied by the myeloperoxidase activity and the H202 concentration increase in 2.6 and 1.4 times, correspondingly (p<0.001). As the "polymorphonuclear leukocytes and myeloperoxidase – H202 – Clˉ " system is the first-line defence against pathogenic microorganisms, the changes mentioned above are likely to be one of the mechanisms enhancing the airways antibacterial immunity in response to the IRS 19 therapy.

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The authors declare that there are no conflicts of interest present.