Tidal expiratory flow limitation in adult cystic fibrosis patients during resting breathing
Abstract
The negative expiratory pressure (NEP) technique is a simple, rapid, noninvasive method for detecting expiratory flow limitation (FL) during spontaneous breathing.
The purpose of this study was to assess the prevalence of FL during resting breathing in adult cystic fibrosis (CF) patients in both the seated and supine positions; and whether FL is associated with dyspnea.
We studied 34 CF patients with the NEP technique and conventional method, based on comparison of tidal and maximal expiratory flow-volume curves. Dyspnea was assessed according to the modified Medical Research Council (MRC) scale. The degree of FL was assessed in terms of a 5-point score according to % control tidal volume encompassed by FL and body position.
With NEP, 6 patients were FL in the seated/supine positions and 3 were FL only in the supine position. By contrast, 20 patients were classified as FL with the conventional method. In a multiple regression analysis FL was the best predictor in assessing the severity of dyspnea.
In conclusion, most stable CF patients do not exhibit tidal FL during resting breathing; detection FL may be useful in the evaluation of dyspnea; and the conventional method for assessing FL may lead to erroneous conclusions.
About the Authors
A. V. Cherniak
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
S. N. Avdeev
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
E. L. Amelina
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
Z. R. Aisanov
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
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Review
For citations:
Cherniak A.V., Avdeev S.N., Amelina E.L., Aisanov Z.R. Tidal expiratory flow limitation in adult cystic fibrosis patients during resting breathing. PULMONOLOGIYA. 2003;(2):100-108. (In Russ.)
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