Analysis of hospitalizations of patients with acute allergic reactions caused by drugs
Abstract
1301 medical histories of patients admitted to a specialized allergologic hospital by the reason of acute allergic disorders (AAD) for 8 yrs (1992 to 1999) were analyzed. More than a half of all the hospitalizations (50.1%) were caused by drug-related allergic disorders. Mainly the drug-related AAD were generated by beta-lactams (17.8%), non-steroid anti-inflammatory drugs (16.6%), vaccines and sera (6.4%). There was a great number of recurrent drug-related AAD. The AAD were typically manifested as urticaria and Quincke’s edema (40.8%), dermatitis (35.6%), and anaphylactic shock (13.7%). The Lyell syndrome in 50% of the cases was caused by sulfonamides.
About the Authors
R. S. Fassakhov
Казанская государственная медицинская академия Минздрава РФ
Russian Federation
Russian Federation
I. D. Reshetnikova
Казанская государственная медицинская академия Минздрава РФ
Russian Federation
Russian Federation
References
1. Лопатин A.C. Лекарственный анафилактический шок. М.: Медицина; 1983.
2. Решетникова И.Д., Фассахов P.C., Низамова И.Г. и др. Место острых аллергических реакций в структуре обращений за скорой медицинской помощью. Аллергология 2000; 4: 3-6.
3. Bates D., Cullen D., Laird N. et al. Incidence of adverse drug events and potential adverse drug events. J.A.M.A. 1995; 274: 29-54.
4. Einarson T.R. Drug-related hospital admission. Ann. Pharma- cother. 1993; 27: 833-840.
5. Lazarou J, Pomeranz B., Corey P. Incidence of adverse druf reactions in hospitalized patients. A meta-analysis of prospective studies. J.A.M.A. 1998; 279: 1200-1205.
Review
For citations:
Fassakhov R.S., Reshetnikova I.D. Analysis of hospitalizations of patients with acute allergic reactions caused by drugs. PULMONOLOGIYA. 2003;(2):28-31. (In Russ.)
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