Detection of inhaled exposure of industrial aerosols
Abstract
The issues of early detection of occupational lung diseases and their prognosis are covered in this article based on modern methods for the assessment of cellular and serum-transferable immunity.
Clinical and immunological examination of 120 patients with industrial dust-related lung diseases and 72 healthy persons exposed to high concentrated industrial dust was performed the recent 3 years. Immune disorders were developing during the exposure period. The severity and specific features of these changes depended on fibrogenic activity of the dust particles. The cellular and serum-transferable immunity disorders were shown to be observed in patients exposed to industrial dust before radiological signs of pulmonary fibrosis and lung function disturbances appeared. After the cessation of the exposure the cellular and serum-transferable immunity parameters did not return to the normal level typical for healthy people.
Methods of clinical immunology make possible early detection and prediction of outcome of lung diseases caused by industrial dust exposure.
About the Authors
V. V. Kosarev
Государственный медицинский университет;
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
A. V. Zhestkov
Государственный медицинский университет;
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
Yu. S. Lebedin
Государственный медицинский университет;
НИИ пульмонологии Минздрава РФ
Russian Federation
Russian Federation
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Review
For citations:
Kosarev V.V., Zhestkov A.V., Lebedin Yu.S. Detection of inhaled exposure of industrial aerosols. PULMONOLOGIYA. 2003;(1):21-24. (In Russ.)
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