Monitoring of allergic inflammation course in atopic bronchial asthma patients
Abstract
Activity levels of NAD(P)-dependent dehydrogenases in blood lymphocytes of 56 atopic asthma children at exacerbation and stable conditions were studied using a bioluminescent method.
A correlation between a character and a degree of the enzyme shifts and, on the other hand, a length and acuity of the disease were found. The changes were more severe and consistent in elderly group (7 to 11 yrs) and during exacerbation of the disease. The parameters of the oxidoreductase activity did not come to normal levels during the stable period. This fact is thought to be one of the reasons of exacerbation occurrence and showed the need of metabolic therapy to correct the intracellular metabolic processes in immunocompetent cells.
The dynamics in the NAD(P)-dependent dehydrogenases activity in blood lymphocytes was shown to reflect a course of the allergic inflammation in the atopic asthma patients and can facilitate the control of its metabolic course, to predict the exacerbation development and to assess a therapy efficacy.
About the Authors
L. M. Kurtasova
Кафедра клинической иммунологии Красноярской государственной медицинской академии;
Краевой центр по профилактике и борьбе со СПИДом
Russian Federation
Russian Federation
A. A. Savchenko
Кафедра клинической иммунологии Красноярской государственной медицинской академии;
Краевой центр по профилактике и борьбе со СПИДом
Russian Federation
Russian Federation
A. R. Shmidt
Кафедра клинической иммунологии Красноярской государственной медицинской академии;
Краевой центр по профилактике и борьбе со СПИДом
Russian Federation
Russian Federation
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Review
For citations:
Kurtasova L.M., Savchenko A.A., Shmidt A.R. Monitoring of allergic inflammation course in atopic bronchial asthma patients. PULMONOLOGIYA. 2003;(5):47-52. (In Russ.)
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