Pulmonary hypertension in Chernobyl clean-up workers
Abstract
The study was designed to investigate pulmonary haemodynamics and to evaluate its role in dyspnoe occurrence in Chernobyl clean-up workers suffering from chronic bronchitis. The study involved 38 Chernobyl patients with chronic bronchitis observed in 2000-2002. The mean age was 48.1 ±5.1 yrs, their smoking history was 18.0±12.7 pack-yrs. A severity of dyspnoe was evaluated with the MRC questionnaire; body plethysmography, lung diffusing capacity test, 6 -MWT, echocardiography, bronchoscopy with transbronchial lung tissue biopsy were also performed. Results demonstrated that pulmonary hypertension develops in Chernobyl workers even without respiratory functional disorders. This fact is probably due to incorporation of radionuclide dust particles to the lungs and occurrence of radiation-induced pulmonary vasculitis. The elimination of the dust particles out of the respiratory system is thought to delay the pulmonary hypertension development.
About the Authors
S. Yu. Chikina
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
G. V. Nekliudova
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
I. D. Kopylev
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
T. L. Pashkova
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
T. A. Korenevskaya
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
A. L. Cherniaev
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
A. G. Chuchalin
НИИ пульмонологии Минздрава России
Russian Federation
Russian Federation
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Review
For citations:
Chikina S.Yu., Nekliudova G.V., Kopylev I.D., Pashkova T.L., Korenevskaya T.A., Cherniaev A.L., Chuchalin A.G. Pulmonary hypertension in Chernobyl clean-up workers. PULMONOLOGIYA. 2003;(6):37-41. (In Russ.)
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