Therapy of reflux-induced bronchial asthma
Abstract
We examined 112 patients with bronchial asthma (BA) of various severity. Twenty of them were diagnosed gastroesophageal reflux by esophagogastroduodenoscopy and esophagotonokymography. The 1st stage reflux esophagitis was detected in 65%, the 2nd stage was in 25% and the 3rd stage was in 10% of the patients. A positive correlation was found between a stage of the reflux esophagitis and severity of lung functional disorders. The conventional treatment of BA resulted in improvement of the patients' status, decreasing in daytime asthma attack rate, but nighttime asthma attacks remained. Differential therapy of reflux esophagitis (diet, change of lifestyle, antacid and prokynetic drugs, high-dosing H2 -blokers, blokers of the hydrogen pump or their combination with prokynetics) reduced the nighttime asthma attack rate by the 5th — the 6 th day and controlled them in all the patients by the 3rd week. The clinilcal signs of the reflux esophagitis disappeared and its endoscopic features diminished. Daily doses of BA basic therapy were decreased in some patients.
About the Authors
E. V. Mashentseva
Кафедра внутренних болезней №1 Государственной медицинской академии
Russian Federation
Russian Federation
A. V. Yagoda
Кафедра внутренних болезней №1 Государственной медицинской академии
Russian Federation
Russian Federation
A. V. Maskina
Кафедра внутренних болезней №1 Государственной медицинской академии
Russian Federation
Russian Federation
O. Yu. Pozdnyakova
Кафедра внутренних болезней №1 Государственной медицинской академии
Russian Federation
Russian Federation
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Review
For citations:
Mashentseva E.V., Yagoda A.V., Maskina A.V., Pozdnyakova O.Yu. Therapy of reflux-induced bronchial asthma. PULMONOLOGIYA. 2003;(6):25-28. (In Russ.)
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