Role of endothelial dysfunction and neoangiogenesis in development of lung fibrosis and pulmonary hypertension in usual interstitial pneumonia
Abstract
The aim of the study was to define a role of endothelial dysfunction and neoangiogenesis in development of lung fibrosis and pulmonary hypertension in usual interstitial pneumonia.
We examined 42 patients with different variants of pulmonary fibrosis: idiopathic pulmonary fibrosis (IPF) and fibrosing alveolitis in diffuse connective tissue diseases (FA-DCTD). The patients' age was 24 to 74 yrs, 50.6 ± 18.8 yrs in average, females predominated (87 %).
We used thrombin-antithrombin III complex (TAT) to evaluate disorders of the plasmatic part of the haemostasis and thrombocyte factor 4 (TF-4), which is a low-weight protein characterized the thrombocyte activity, to assess thrombocyte part of the haemostasis. TAT and TF-4 plasma concentrations were measured with the ELISA. Control values were gained from 16 healthy volunteers. Our study reliably showed activation of the coagulation and thrombocyte aggregation in patients with pulmonary fibrosis proved by the significant growth of the TF-4 and TAT levels, which are early stable and highly sensitive markers of thrombophilia, in 1.58 and 1.6 times respectively compared with the controls. The TAT maximal concentration was found in the IPF patients and the TF-4 maximal level was displayed in the FA-DCTD patients (p < 0.007 and p < 0.05 correspondingly compared with the controls). So, the revealed features of the haemostasis evidence a great role of the thrombophilia in lung sclerotic processes in interstitial lung diseases. The high TAT and TF-4 activities correlate with severe remodeling of the lung interstitial tissue and can be used as early markers of lesions of the pulmonary vessels and of possible thromboembolic complications in interstitial lung diseases.
About the Authors
E. N. Popova
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
D. V. Arkhipova
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
E. A. Kogan
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
L. V. Kozlovskaya
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
В. M. Kornev
ММА им. И.М.Сеченова
Russian Federation
Russian Federation
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Review
For citations:
Popova E.N., Arkhipova D.V., Kogan E.A., Kozlovskaya L.V., Kornev В.M. Role of endothelial dysfunction and neoangiogenesis in development of lung fibrosis and pulmonary hypertension in usual interstitial pneumonia. PULMONOLOGIYA. 2004;(3):16-21. (In Russ.)
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