Influence of Ассоlate on leukotriene production in patients with aspirin-induced asthma

Abstract

We studied preventive effect of leukotriene receptors' antagonist Accolate on aspirin-induced bronchoconstriction in 18 patients with aspirin-induced asthma (AA) proved by a challenge test. The drug prevented the aspirin-induced bronchospasm in 14 patients and was ineffective in 4 ones having severe course of the disease including 2 of them with combination of AA and atopic asthma. Clinical efficacy of 4-week therapy with Accolate correlated with the test results: 4 patients had not experienced the preventive effect of the drug did not show positive shifts in their asthma course. The asthma attack rate significantly reduced in 14 patients, need in sympathomimetics dropped in 1.5 times. These findings allowed the predictive test to select patients for long-term therapy with Accolate. A significant increase in the supernatant C4, E4, and B4 leukotrienes outbreak was shown in all the AA patients after incubation of the leukocytes with aspizole initially and in 1 hour after taking Accolate.