Polymorphic variants of pro-inflammatory cytokine genes as markers of predisposition for chronic obstructive lung disease
Abstract
The distribution of pro-inflammatory cytokine gene variants (tumour necrosis factor α-TNF, lymphotoxin — LTA, interleukin-1β — IL-1β) was studied in 139 patients with chronic obstructive lung disease (COPD) and in healthy individuals (n = 210). Analysis of -308G/A locus of TNF gene did not reveal significant difference between patients and controls (p > 0.05). It was observed that LTA genotypes were associated with COPD severity. Marked prevalence of AG heterozygous genotype was noted in patients with II and III COPD stages (59.7 % and 55.0 % accordingly), but IV stage COPD patients had increased frequency of GG homozygous mutant genotype up to 11.5 %. The GG genotype of the LTA gene in smokers strongly associated with more severe COPD (OR = 5.21,95%CI: 1.48-18.52). Among patients with -511C/T locus of IL-1β gene, 90.4 % had III and IV COPD stages. Thus, the T/T mutant homozygous patients had a 4.4-fold increased risk for very severe COPD development. TNF/LTA genotype combinations were determined for various COPD stages.
About the Authors
D. G. Yanbaeva
Институт биохимии и генетики Уфимского научного центра Российской академии наук
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
No
O. V. Bainak
Башкирский государственный медицинский университет
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
No
G. F. Korytina
Институт биохимии и генетики Уфимского научного центра Российской академии наук
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
No
Sh. Z. Zagidullin
Башкирский государственный медицинский университет
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
No
T. V. Viktorova
Институт биохимии и генетики Уфимского научного центра Российской академии наук
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
No
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Review
For citations:
Yanbaeva D.G., Bainak O.V., Korytina G.F., Zagidullin Sh.Z., Viktorova T.V. Polymorphic variants of pro-inflammatory cytokine genes as markers of predisposition for chronic obstructive lung disease. PULMONOLOGIYA. 2004;(5):17-22. (In Russ.)
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