pulmoПульмонологияPULMONOLOGIYA0869-01892541-9617Scientific and Practical Journal “PULMONOLOGIYA” LLCpulmo-2470Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL STUDIESПолиморфные варианты генов провоспалительных цитокинов как маркеры предрасположенности к хронической обструктивной болезни легкихPolymorphic variants of pro-inflammatory cytokine genes as markers of predisposition for chronic obstructive lung diseaseЯнбаеваД. Г.YanbaevaD. G.БайнакО. В.BainakO. V.КорытинаГ. Ф.KorytinaG. F.ЗагидуллинШ. З.ZagidullinSh. Z.ВиктороваТ. В.ViktorovaT. V.Институт биохимии и генетики Уфимского научного центра Российской академии наукRussian FederationБашкирский государственный медицинский университетRussian Federation200417082021051722Copyright © Янбаева Д.Г., Байнак О.В., Корытина Г.Ф., Загидуллин Ш.З., Викторова Т.В., 20212021Янбаева Д.Г., Байнак О.В., Корытина Г.Ф., Загидуллин Ш.З., Викторова Т.В.Yanbaeva D.G., Bainak O.V., Korytina G.F., Zagidullin S.Z., Viktorova T.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://journal.pulmonology.ru/pulm/article/view/2470

Изучено распределение вариантов генов, кодирующих провоспалительные цитокины: фактор некроза опухоли-α — TNF-α, лимфотоксин-α — LTA, интерлейкин-1β— IL-1β, у 139 пациентов с хронической обструктивной болезнью легких (ХОБЛ) различной степени тяжести и у здоровых индивидов (n = 210). При анализе полиморфизма -308G/A гена TNF различий между исследуемыми группами не обнаружено. По локусу +252A/G гена LTA выявлены генотипы, ассоциированные с тяжестью течения ХОБЛ: у больных со II и III стадиями ХОБЛ отмечено преобладание гетерозиготного генотипа AG (59,7 % и 55,0 % соответственно), тогда как у больных с IV стадией ХОБЛ увеличена частота генотипа GG до 11,5 %. Генотип GG в гене LTA в сочетании с таким фактором риска как курение значительно отягощает прогноз тяжести течения заболевания (OR = 5,21, 95%CI 1,48-18,52). Среди всех больных с генотипом ТТ гена IL-1β (полиморфизм -511С/Т) 90,4 % приходилось на пациентов III и IV стадий ХОБЛ. Соответственно, при наличии генотипа ТТ риск развития крайне тяжелой формы ХОБЛ (стадия IV) оказался повышен в 4,4 раза (OR = 4,4, 95%CI 0,92-29,13). По генам TNF и LTA определены комбинации генотипов, маркирующие тяжесть клинического течения ХОБЛ.

The distribution of pro-inflammatory cytokine gene variants (tumour necrosis factor α-TNF, lymphotoxin — LTA, interleukin-1β — IL-1β) was studied in 139 patients with chronic obstructive lung disease (COPD) and in healthy individuals (n = 210). Analysis of -308G/A locus of TNF gene did not reveal significant difference between patients and controls (p > 0.05). It was observed that LTA genotypes were associated with COPD severity. Marked prevalence of AG heterozygous genotype was noted in patients with II and III COPD stages (59.7 % and 55.0 % accordingly), but IV stage COPD patients had increased frequency of GG homozygous mutant genotype up to 11.5 %. The GG genotype of the LTA gene in smokers strongly associated with more severe COPD (OR = 5.21,95%CI: 1.48-18.52). Among patients with -511C/T locus of IL-1β gene, 90.4 % had III and IV COPD stages. Thus, the T/T mutant homozygous patients had a 4.4-fold increased risk for very severe COPD development. TNF/LTA genotype combinations were determined for various COPD stages.

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The authors declare that there are no conflicts of interest present.