Morphological changes of respiratory muscles in patients with chronic obstructive pulmonary disease and different severity of respiratory failure
Abstract
Morphologic examination of respiratory muscles in 71 cases using light and electronic microscopy and morphometry revealed respiratory muscle pathology in COPD patients with different severity of respiratory failure. Mild respiratory failure was characterized by dystrophic and hypertrophic changes prevailed, moderate respiratory failure showed predominant necrotic changes, severe respiratory failure was accompanied by fibrotic tissue spread in necrotic foci and in stroma. The greatest lesions were observed in the inner intercostal muscles, and the slightest ones were in the diaphragm. The morphometric study revealed shifts of the ratio of the parenchyma and stroma due to enlargement of the stromal component. Correlations were found between the latter parameters and FEV1 (forced expiratory volume at one second).
About the Author
I. S. Platonova
НИИ пульмонологии Государственного медицинского университета им. акад. И.П. Павлова
Russian Federation
Competing Interests:
Russian Federation
Competing Interests:
No
References
1. Calore Е.Е., Sesso A., Puga F., et al. Early expression of ubiquitin in myofibers of rats in organophosphate intoxication // J. Ecotoxicol.Environ. — 1999. — Vol. 43, N. 2. — P. 187-194.
2. Fontana M.D., Gea J., 1998 Farkas G.A., Gosselin L.E., Zhan W.Z. et al. Histochemical and mechanical properties of diaphragm muscle in morbidly obese Zucker rats // J. Appl. Physiol. — 1994. — Vol. 77, № 5. — P. 2250-2259.
3. Shrager Y.B., Kim D.K., Hashmi Y.J. et al. Sarcomeres are added in series to emphysematous rat diaphragm after lung volume reduction surgery // J. Chest. — 2002. — Vol. 121, № 1. — P. 210-215.
4. Tomilin N.V., Kuznetsov V.G., Mashanskii V.F. et al. Ultrastructure of neuromuscular synapses of 3 types of muscle fibers of the rat diaphragm in acute chlorophos poisoning // J. Arkh. Anat. Gistol. Embriol. — 1990. — Vol. 99, №9. — P. 20-25.
5. Beljanski-Conkic R., Kuruc V. Morphologic and Morphometric Characteristics of Inspiratory Muscles in Patients with and without Respiratory Insuffitienty (RI) // Eur. Respir. J. — 1996. — Vol. 9, Suppl. 23. — P. 72.
6. Jimenez-Fuentes M.A., Gea J., Aguar M.C., Minguella J Llo-reta J. et al. Capillary density and respiratory function in the external intercostals muscle. // J. Arch Bronconeumol. — 1999. — Vol. 35, № 10. — P. 471-476. 130.
7. Бузуева И.И., Филюшина Е.Е., Шмерлинг М.Д. Изменения ультраструктуры мышечных волокон диафрагмы при физических нагрузках (морфометрический метод) // Архив анатомии, гистологии, эмбриологии. — 1986. — №6. — С.45-53.
8. Саркисов Д. С. Структурные основы адаптации и компенсации нарушенных функций / Руководство. — М. — 1987.
9. Farkas G.A., Gosselin L.E., Zhan W.Z. et al. Histochemical and mechanical properties of diaphragm muscle in morbidly obese Zucker rats // J. Appl. Physiol. — 1994. — Vol. 77, № 5. — P. 2250-2259.
10. Cruz-Hofling M.A., Rodrigues-Simioni L. In vitro studies ol the ultrastructural changes induced by guanidine in the nerves, muscle fibers and neuromuscular junction of the mouse diaphragm // J.Gen. Pharmacol. — 1998. — Vol. 130, №5. — P. 705-11.
11. Campbell J.A., Richard L., Sahgal V. Alterations in Intercostal Muscle Morphology and Biochemistry in Patients with Obstructive Lung Disease // American Review of Respiratory Disease. — 1980. — Vol. 122.
12. Gea J., Pasto M., Carmona M.A. et al. Metabolic characteristics of the deltoid muscle in patients with chronic obstructive pulmonary disease // J. Eur. Respir. — 2001. — Vol. 17. — P. 935 — 945.
13. Marini J.J. Fiber Properties and Orientation // J. Respiratory Medicine for the House Officer. — 1987. — P. 32.
Review
For citations:
Platonova I.S. Morphological changes of respiratory muscles in patients with chronic obstructive pulmonary disease and different severity of respiratory failure. PULMONOLOGIYA. 2004;(5):23-27. (In Russ.)
Views:
257
Email this article 