The association of IL-4 and IL-4RA genes polymorphism with pulmonary ventilation function and pathogenic signs of atopic bronchial asthma
Abstract
An attempt was made to discover pathogenic links between gene polymorphism of interleukin-4 which is "the critical inflammatory cytokine", atopic features, respiratory function and bronchial hyperresponsiveness (BHR) in 70 families of atopic asthma patients. Spirometry, methacholine challenge test ("MasterLab pro"), serum total IgE level, serum IL-4 level (by the ELISA method), skin prick tests ("Immuno Tek"), IL-4 (-589C /T, G /C З'-utr) and IL-4RA (lleSOVal, Glu551Arg) genes polymorphism were investigated in 70 probands (11.6 ± 1.2 yrs) and 247 relatives (36.7 ± 1.2 yrs) from Tomsk region (Siberia). Significant associations of certain variants of polymorphous IL-4 and IL-4RA genes with bronchial airflow param eters (FEVt), atopic features (increased IgE level), and bronchial asthma severity were found. Patients with persistent mild, moderate, and severe asthma had their proper variations of polymorphism. The methacholine challenge test was an objective marker of BHR in this study but any associations between BHR and IL-4 and IL-4RA polymorphous variants were not found.
About the Authors
A. V. Dubakov
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
M. B. Freydin
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
F. F. Tetenev
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
L. M. Ogorodova
Сибирский государственный медицинский университет
Russian Federation
Russian Federation
V. P. Puzyrev
НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
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Review
For citations:
Dubakov A.V., Freydin M.B., Tetenev F.F., Ogorodova L.M., Puzyrev V.P. The association of IL-4 and IL-4RA genes polymorphism with pulmonary ventilation function and pathogenic signs of atopic bronchial asthma. PULMONOLOGIYA. 2004;(4):10-15. (In Russ.)
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