Evaluation of clinical and functional status and quality of life in COPD patients before and after out-patient medication therapy
Abstract
A comparative randomised trial of fenspirid (Erespal) had been administered for 3 months together with bronchodilating and mycolytic drugs involved 45 patients with chronic obstructive pulmonary disease (COPD). Clinical status, forced expiratory values and quality of life (QoL) were studied using World Organization of Health questionnaire (W H O Q O L -100). Thirty four patients completed the examination (24 males and 10 females, the average age was 52.7±1.9 yrs). The comparative group included 25 healthy non-smokers. The trial demonstrated that the therapy resulted in improvement of QoL in physical and psychical health scales. The patients becam e more active, their sleep becam e better. Their attention was transferred from their physical status to the surroundings. The application of fenspirid (Erespal) facilitated the improvement in the forced expiratory values and ESR. The drug was well tolerated and caused only mild adverse effects which rates were equal to those in patients not received fenspirid. The results permit fenspirid to be included to modern treatment protocols for patients with mild to moderate COPD when combined with bronchodilators.
About the Authors
A. A. Visel
Казанский государственный медицинский университет Минздрава РФ
Russian Federation
Russian Federation
I. Yu. Visel
Казанский государственный медицинский университет Минздрава РФ
Russian Federation
Russian Federation
E. S. Ryumina
Казанский государственный медицинский университет Минздрава РФ
Russian Federation
Russian Federation
M. E. Guryleva
Казанский государственный медицинский университет Минздрава РФ
Russian Federation
Russian Federation
References
1. Шмелев Е.И. ХОБЛ: ключевые проблемы. Атмосфера: Пульмонол. и аллергол. 2003; 2 (9): 5-9.
2. Feinlieb М., Rosenberg N.M., Collins J.G. et al. Trends in COPD morbidity and mortality in the United States. Am. Rev. Respir. Dis. 1989; 140: 9-18.
3. Васильева O.C. Воздействие факторов окружающей среды и хроническая обструктивная болезнь легких. Пульмонология: Избран, вопр. 2003; 6: 1-4.
4. Синопальников А.И. Фармакотерапия хронического обструктивного бронхита: Метод, пособие. М.; 1997.
5. Визель А.А., Гильманов А.А., Самерханова А.Э. и др. Сопоставление острого бронхолитического эффекта небулизации растворов беродуала и сальгима у больных хроническим обструктивным бронхитом и бронхиальной астмой. Тер. арх. 2002; 74 (8): 49-52.
6. Сухов В.М., Кузьмин А.З., Чернышева И.С., Визель А.А. Обоснование и эффективность лечения ингакортом больных хроническим бронхитом. Казан, мед. журн. 1998; 2: 92-93.
7. Akoun G., Arnaud F., Blanchon F. et al. Effect of fenspiride on airway function and blood gases in stable COPD patient. Eur. Respir. Rev. 1991; l(rev. 2): 51-65
8. Quartulli F., Pinelli E., Broue-Chabbert A. et al. Fenspiride inhibits histamine-induced responses in a lung epithelial cell line. Eur. J. Pharmacol. 1998; 348 (2-3): 297-304.
9. Khawaja A M ., Liu Y.C., Rogers D.F. Effect of fenspiride, a non-steroidal antiinflammatory agent, on neurogenic mucus secretion in ferret trachea in vitro. Pulm. Pharmacol. Ther. 1999; 12 (6): 363-368.
10. Plusa T„ Nawacka D. Efficacy and tolerance of fenspiride in adult patients with acute respiratory tract infections. Pol. Merkuriusz. Lek. 1998; 5 (30): 368-371.
11. Lirsac B., Benezet O., Dansin E. et al. Evaluation and symptomatic treatment of surinfectious exacerbations of COPD: preliminary study of antibiotic treatment combined with fenspiride (Pneumorel 80 mg) versus placebo. Rev. Pneumol. Clin. 2000; 56 (1): 17-24.
12. Куницына Ю.Л., Шмелев Е.И. Противовоспалительная терапия больных при хронической обструктивной болезни легких. Пульмонология 2003; 2: 111-116.
13. Безлепко А.В. Опыт длительного применения эреспала при лечении больных хроническим обструктивным бронхитом. Пульмонология: Избран, вопр. 2002; 2: 14.
14. Визель А.А. Белиловский Е.М., Соколов Н.Г., Галков Е.М. Логическое правило интерпретации внешнего дыхания и его реализация на микро-ЭВМ: Метод, рекомендации. Казань; 1990.
Review
For citations:
Visel A.A., Visel I.Yu., Ryumina E.S., Guryleva M.E. Evaluation of clinical and functional status and quality of life in COPD patients before and after out-patient medication therapy. PULMONOLOGIYA. 2004;(1):60-67. (In Russ.)
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