CLINICAL AND MORPHOLOGICAL FEATURES OF ENTEROENDOCRINE SYSTEM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE
https://doi.org/10.18093/0869-0189-2014-0-2-50-54
Abstract
Introduction. Comorbidity greatly contributes to progression and severity of chronic obstructive pulmonary disease (COPD). The aim of this study was to describe the nature and severity of gastrointestinal paraendocrine disorders in patients with COPD.
Methods. This cross-sectional open randomized controlled study included 84 patients with COPD. We measured blood serotonin concentration and performed immunohistochemical investigation of gastrointestinal APUD cells.
Results. Our results suggested an effect of gastrointestinal disease on the severity of COPD. Hyperserotoninemia and structural and functional disorders in enteroendocrine system were noted even in patients with mild COPD.
Conclusion. The severity of bronchial obstruction could correlate with functional activity of serotonin-producing enteroendocrine cells.
Methods. This cross-sectional open randomized controlled study included 84 patients with COPD. We measured blood serotonin concentration and performed immunohistochemical investigation of gastrointestinal APUD cells.
Results. Our results suggested an effect of gastrointestinal disease on the severity of COPD. Hyperserotoninemia and structural and functional disorders in enteroendocrine system were noted even in patients with mild COPD.
Conclusion. The severity of bronchial obstruction could correlate with functional activity of serotonin-producing enteroendocrine cells.
About the Authors
L. M. Kamalova
ФГБУ "Уральский государственный медицинский университет" Минздрава России: 620000, Екатеринбург, ул. Репина, 3
МАУ "Городская клиническая больница № 40": 620102, Екатеринбург, ул. Волгоградская, 189
Russian Federation
Russian Federation
T. V. Lisovskaya
ФГБУ "Уральский НИИ охраны материнства и младенчества" Минздрава России: 620102, Екатеринбург, ул. Репина, 1
Russian Federation
Russian Federation
S. Yu. Medvedeva
ФГБУН "Институт иммунологии, физиологии УрО РАН": 620049, Екатеринбург, ул. Первомайская, 106
Russian Federation
Russian Federation
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Review
For citations:
Kamalova L.M., Lisovskaya T.V., Medvedeva S.Yu. CLINICAL AND MORPHOLOGICAL FEATURES OF ENTEROENDOCRINE SYSTEM IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE. PULMONOLOGIYA. 2014;(2):50-54. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-2-50-54
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