POSSIBILITIES TO DETECT VASCULAR INVASION AND ITS PROGNOSTIC ROLE IN PATIENTS WITH OPERABLE NON-SMALL CELL LUNG CARCINOMA
https://doi.org/10.18093/0869-0189-2014-0-2-40-43
Abstract
Introduction. Vascular invasion in operable lung cancer is an important prognostic factor. Vascular invasion worsens prognosis even in absence of metastases and could require adjuvant chemotherapy. The aims of this study were: 1) to investigate vascular invasion in surgical specimens of non-small cell lung carcinomas (NSCLC) using immunohistochemical detection of CD34+, actin, and cytokeratine expression; 2) to estimate prognostic values of these markers.
Methods. Surgical specimens were obtained from 60 patients with NSCLC Т2N0М0 to T3N2M0 stages aged 51 to 73 years (88.3 % were males).
Results. Vascular invasion found in primary malignancy significantly worsened outcomes (р = 0.0184) and survival.
Conclusion. Vascular invasion is an important predictive factor in patients with malignancies including NSCLC. Immunohistochemistry allowed better detection this process. The most valuable marker is to be CD34+.
Methods. Surgical specimens were obtained from 60 patients with NSCLC Т2N0М0 to T3N2M0 stages aged 51 to 73 years (88.3 % were males).
Results. Vascular invasion found in primary malignancy significantly worsened outcomes (р = 0.0184) and survival.
Conclusion. Vascular invasion is an important predictive factor in patients with malignancies including NSCLC. Immunohistochemistry allowed better detection this process. The most valuable marker is to be CD34+.
About the Authors
S. A. Zin'kovich
ФГБУ "Ростовский научно-исследовательский онкологический институт" Минздрава России: 344037, Ростов-на-Дону, 14-я линия, 63
Russian Federation
Russian Federation
E. M. Nepomnyashchaya
ФГБУ "Ростовский научно-исследовательский онкологический институт" Минздрава России: 344037, Ростов-на-Дону, 14-я линия, 63
Russian Federation
Russian Federation
Yu. N. Lazutin
ФГБУ "Ростовский научно-исследовательский онкологический институт" Минздрава России: 344037, Ростов-на-Дону, 14-я линия, 63
Russian Federation
Russian Federation
P. A. Anistratov
ФГБУ "Ростовский научно-исследовательский онкологический институт" Минздрава России: 344037, Ростов-на-Дону, 14-я линия, 63
Russian Federation
Russian Federation
T. O. Lapteva
ФГБУ "Ростовский научно-исследовательский онкологический институт" Минздрава России: 344037, Ростов-на-Дону, 14-я линия, 63
Russian Federation
Russian Federation
O. V. Tarnopol'skaya
ФГБУ "Ростовский научно-исследовательский онкологический институт" Минздрава России: 344037, Ростов-на-Дону, 14-я линия, 63
Russian Federation
Russian Federation
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Review
For citations:
Zin'kovich S.A., Nepomnyashchaya E.M., Lazutin Yu.N., Anistratov P.A., Lapteva T.O., Tarnopol'skaya O.V. POSSIBILITIES TO DETECT VASCULAR INVASION AND ITS PROGNOSTIC ROLE IN PATIENTS WITH OPERABLE NON-SMALL CELL LUNG CARCINOMA. PULMONOLOGIYA. 2014;(2):40-43. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-2-40-43
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