EFFICACY OF SODIUM MONTELUKAST IN TREATMENT OF CHILDHOOD ASTHMA OF VARIOUS PHENOTYPES
https://doi.org/10.18093/0869-0189-2011-0-1-74-80
Abstract
Summary. Effects of 12-week course of sodium montelukast (Singular) on lung function, bronchial hyperresponsiveness and markers of eosinophilic inflammation have been analyzed in children with atopic and non-atopic asthma and recurrent bronchitis with allergic rhinitis. The study involved 69 children aged 3 to 16 years. The study results showed that sodium montelukast significantly decreased lung hyperinflation and obstructive ventilator disorders, recovered bronchial receptor sensitivity and controlled the eosinophilic inflammation. The effect was the most significant in children with non-atopic asthma including the complete normalization of lung function.
About the Authors
N. V. Kukhtinova
Новосибирский государственный медицинский университет
Russian Federation
Russian Federation
к. м. н., ассистент кафедры педиатрии
630091, Новосибирск, Красный пр6т, 52.
Тел.: (383) 223-67-21.
E. G. Kondyurina
Новосибирский государственный медицинский университет
Russian Federation
Russian Federation
д. м. н., проф., проректор по ПДО, зав. каф. педиатрии
630091, Новосибирск, Красный пр6т, 52.
Тел.: (383) 222-08-33.
References
1. Национальная программа. Бронхиальная астма у детей. Стратегия лечения и профилактика. 3-е изд. М.: Издат. дом "Атмосфера"; 2008.
2. Proesmans M., Sauer K., Govaere E. et al. Montelucast does not prevent reactive airway disease in young children hospitalized for RSV bronchiolitis. Acta Paediatr. 2009; 98 (11): 1830–1834.
3. Quanjer P.H., Tammeling G.J., Cotes J.E. et al. Lung volumes and forced ventilatory flows. Eur. Respir. J. 1993; 16 (Suppl. 6): 5–40.
4. Joseph-Bowen J., de Klerk N., Holt P.G., Sly P.D.Relationship of asthma, atopy and bronchial responsiveness to serum eosinophil cationic proteins in early childhood.J. Allergy Clin. Immunol. 2004; 114 (5): 1040–1045.
5. Bibi H., Montgomery M., Pasterkamp H., Chernick V. Relationship between response to inhaled salbutamol and methaholine bronchial provocation in children with suspected asthma. Pediatr. Pulmonol. 1991; 10: 244–248.
6. Mastruzzo C., Contrafatto M.R., Crimi C. et al. Acute additive effect of montelukast and beclomethasone on AMP induced bronchoconstriction. Respir. Med. 2010; 12:18–26.
7. Anderson S.D., Brannan J.D., Perry C.P. et al. Sodium cromoglycate alone and in combination with montelukast on the airway response to mannitol in asthmatic subjects.J. Asthma 2010; 47 (4): 429–433.
8. Pedersen S.E., Hurd S.S., Lemanske R.F. et al. Global strategy for the diagnosis and management of asthma in children 5-years and younger. Pediatr. Pulmonol. 2010.
9. Buchele G., Genuneit J., Weinmayr G. et al. International variations in bronchial responsiveness in children. Pediatr Pulmonol. 2010; 45 (8): 796–806.
10. Pinto L.A., Stein R.T., Riberio J.D. Genetic assotiation with asthma and virus induced wheezing. J. Bras. Pneumol.2009; 35 (12): 541–545.
11. Amin K., Ludviksdottir D., Jonson C. et al. Inflammation and structural changes in the airways of patients with atopic and nonatopic asthma. Am. J. Respir. Crit. Care Med. 2000; 162 (6): 2295–2301.
12. Bacharier L.B., Phillips B.R., Zeiger R.S. et al. Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate to severe intermittent wheezing. J. Allergy Clin. Immunol. 2008; 122 (6):1127–1135.
Review
For citations:
Kukhtinova N.V., Kondyurina E.G. EFFICACY OF SODIUM MONTELUKAST IN TREATMENT OF CHILDHOOD ASTHMA OF VARIOUS PHENOTYPES. PULMONOLOGIYA. 2011;(1):74-80. (In Russ.) https://doi.org/10.18093/0869-0189-2011-0-1-74-80
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