HEPCIDIN IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA COMPLICATED BY ANAEMIA
https://doi.org/10.18093/0869-0189-2014-0-2-5-9
Abstract
The aim of this study was to analyze relationships between hepcidin concentration in blood and other nflammation mediators, blood erythropoietin and iron metabolism in patients with community-acquired pneumonia complicated by anaemia. Methods. Blood hepcidin concentration in 64 patients with community-acquired pneumonia has been measured. Results. Abrupt increase in hepcidin concentration in these patients seemed to demonstrate its relationship to inflammation through the interleukine6 production. Hepcidin was also related to increased ferritin concentration and could induce hypoferremia and inflammation-related anaemia while blood erythropoietin concentration was inversely related to hemoglobin, erythrocyte and hepcidin concentrations. Conclusion. The results allow us suggestion that synthesis of hepcidin is regulated not only by inflammation but also by anaemia and hypoxia.
About the Authors
E. N. Nikitin
ГБОУ ВПО "Ижевская государственная медицинская академия Минздрава России": 426034, Удмуртская Республика, Ижевск, ул. Коммунаров, 281
Russian Federation
Russian Federation
Yu. E. Nikitin
ГБОУ ВПО "Ижевская государственная медицинская академия Минздрава России": 426034, Удмуртская Республика, Ижевск, ул. Коммунаров, 281
Russian Federation
Russian Federation
A. E. Shklyaev
ГБОУ ВПО "Ижевская государственная медицинская академия Минздрава России": 426034, Удмуртская Республика, Ижевск, ул. Коммунаров, 281
Russian Federation
Russian Federation
O. V. Aleksandrova
ГБОУ ВПО "Ижевская государственная медицинская академия Минздрава России": 426034, Удмуртская Республика, Ижевск, ул. Коммунаров, 281
Russian Federation
Russian Federation
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Review
For citations:
Nikitin E.N., Nikitin Yu.E., Shklyaev A.E., Aleksandrova O.V. HEPCIDIN IN PATIENTS WITH COMMUNITY-ACQUIRED PNEUMONIA COMPLICATED BY ANAEMIA. PULMONOLOGIYA. 2014;(2):5-9. (In Russ.) https://doi.org/10.18093/0869-0189-2014-0-2-5-9
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