Current opportunities of inhaled corticosteroid therapy in patients with chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2021-31-1-75-87
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Abstract
Chronic obstructive pulmonary disease (COPD) is the leading cause of death in the structure of respiratory diseases. The problem of rational pharmacotherapy of COPD have attracted attention of the medical scientific society for many years. The understanding of the pathogenesis of the disease has deepened and approaches to the therapy have changed. Some COPD patients need regular fixed-combination therapy: long-acting bronchodilators (LABD) and inhaled corticosteroids (ICS) in order to prevent exacerbations and reduce the severity of symptoms of the disease. Blood eosinophils count is one of criteria for choosing regular therapy. The appearance of fixed triple combinations of ICS/LABD increased the effectiveness of COPD therapy, and a new delivery device for fixed combination of budesonide/formoterol makes it possible to use ICS successfully in the most severe patients.
About the Authors
I. V. Leshchenko
Ural Federal State Medical University, Healthcare Ministry of Russia; Ural Research Institute of Phthisiopulmonology - a branch of National Medical Research Phthisiopulmonology and Infectious Diseases Center, Healthcare Ministry of Russia
Russian Federation
Competing Interests: The authors declare no conflict of interest.
Russian Federation
Igor V. Leshchenko - Doctor of Medicine, Professor, Department of Phthisiology and Pulmonology, Ural State Medical University, Healthcare Ministry of Russia, Chief Researcher, Ural Research Institute of Phthisiopulmonology -a branch of National Medical Research Phthisiopulmonology and Infectious Diseases Center, Healthcare Ministry of Russia.
ul. Repina 3, Ekaterinburg, 620028; ul. 22nd Parts'ezda 50, Sverdlovskaya obl., Ekaterinburg, 620039.
tel.: (343) 246-44-75
Competing Interests: The authors declare no conflict of interest.
A. S. Meshcheryakova
“AstraZeneca Pharmaceuticals” Limited Liability Company
Russian Federation
Competing Interests: The authors declare no conflict of interest.
Russian Federation
Anastasiya S. Meshcheryakova - Medical Scientific Liaison, Respiratory & Immunology Ural, “AstraZeneca Pharmaceuticals” Limited Liability Company.
1st Krasnogvardeyskiy pr. 21, build. 1, Moscow, 123112.
tel.: (904) 985-26-44
Competing Interests: The authors declare no conflict of interest.
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For citations:
Leshchenko I.V., Meshcheryakova A.S. Current opportunities of inhaled corticosteroid therapy in patients with chronic obstructive pulmonary disease. PULMONOLOGIYA. 2021;31(1):75-87. (In Russ.) https://doi.org/10.18093/0869-0189-2021-31-1-75-87
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ISSN 2541-9617 (Online)
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