The role of B-lymphocytes in inflammation in chronic obstructive pulmonary disease and bronchial asthma
https://doi.org/10.18093/0869-0189-2020-30-6-729-734
Abstract
An important role in airway inflammation in cases of bronchial asthma (BA) and chronic obstructive pulmonary disease (COPD) is played by immune responses.
Methods. In order to identify the signs of impaired functioning of the immune system in patients with COPD (n = 39) and BA (n = 37), the number and activity of lymphocytes expressing CD20, CD23, CD25, CD71, CD72, HLA-DR antigens were studied in blood serum; their role in inflammation during the period of exacerbation and a stable course of diseases was evaluated.
Results. Examined patients, being in both stages of the disease, revealed a significant increase in the number of B-lymphocytes of all stages of differentiation. Insufficient apoptosis was also noted, which indicates the activation of the B-cell component of the immune system.
Conclusion. According to the study results, it was found that the increased activity of B-cells, on the one hand, protects the body from colonization by microorganisms and infection (in COPD), by blocking the formation of immunoglobulin E (in BA), on the other hand, the autoantibodies, which they produce, can damage their own tissue, and insufficient apoptosis process may lead to maintenance of the inflammation process.
About the Authors
N. A. Raspopina
I.M.Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia; M.F.Vladimirskiy State Moscow Regional Research Clinical Institute
Russian Federation
Competing Interests: declare the absence of conflict of interests
Russian Federation
Natal’ya A. Raspopina - Doctor of Medicine, Professor, Department of Pulmonology, Medical Faculty, I.M.Sechenov First MSMU (Sechenov University), Healthcare Ministry of Russia, Professor of Therapy Department, Faculty of Advanced Medical Education, M.F.Vladimirskiy SMRRCI.
Ul. Trubetskaya 8, build. 2, Moscow, 119991; Ul. Shchepkina 61/2, Moscow, 129110; tel.: (903) 591-22-77Competing Interests: declare the absence of conflict of interests
E. G. Shuganov
I.M. Sechenov First Moscow State Medical University (Sechenov University), Healthcare Ministry of Russia; M.F. Vladimirskiy State Moscow Regional Research Clinical Institute
Russian Federation
Competing Interests: declare the absence of conflict of interests
Russian Federation
Evgeny G. Shuganov, Doctor of Medicine, Professor, Professor of Therapy Department, Faculty of Advanced Medical Education, M.F.Vladimirskiy SMRRCI, Professor, Department of Pulmonology, Medical Faculty, I.M.Sechenov First MSMU (Sechenov University).
Ul. Trubetskaya 8, build. 2, Moscow, 119991; Ul. Shchepkina 61/2, Moscow, 129110; tel.: (495) 631-72-84
Competing Interests: declare the absence of conflict of interests
Zh. M. Salmasi
N.I. Pirogov Federal Russian National Research Medical University, Healthcare Ministry of Russia
Russian Federation
Competing Interests: declare the absence of conflict of interests
Russian Federation
Zhean M. Salmasi - Doctor of Medicine, Head of Department of Pathological Physiology and Clinical Pathophysiology, Medical Faculty.
Ul. Ostrovityanova 1, Moscow, 117997; tel.: (495) 434-63-12
Competing Interests: declare the absence of conflict of interests
A. E. Shuganov
M.F.Vladimirskiy State Moscow Regional Research Clinical Institute
Russian Federation
Competing Interests: declare the absence of conflict of interests
Russian Federation
Aleksandr E. Shuganov - Candidate of Medicine, Researcher.
Ul. Shchepkina 61/2, Moscow, 129110; tel.: (906) 753-38-79
Competing Interests: declare the absence of conflict of interests
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For citations:
Raspopina N.A., Shuganov E.G., Salmasi Zh.M., Shuganov A.E. The role of B-lymphocytes in inflammation in chronic obstructive pulmonary disease and bronchial asthma. PULMONOLOGIYA. 2020;30(6):729-734. (In Russ.) https://doi.org/10.18093/0869-0189-2020-30-6-729-734
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