Features of pulmonary haemodynamics and endothelium function in children with asthma
https://doi.org/10.18093/0869-0189-2007-0-4-56-59
Abstract
Asthma patients (n = 79, 7 to 17 years of age) were divided into 3 groups according to asthma severity: mild (n = 23), moderate (n = 24), and severe asthma (n = 32). Asthma was diagnosed according to GINA (2002). Echocardiography, ultrasound evaluation of endothelium vasomotor function and measurement of nitrite anion concentration in exhaled breathe condensate (EBC) were performed in the all patients. Right ventricle dilatation and increase in the total pulmonary vascular resistance were revealed only in patients with severe asthma compared to the control group. Increase in pulmonary artery systolic pressure was significantly higher in the severe asthma patients compared both to the control group and mild asthma patients. Increased right ventricle pressure was accompanied by endothelium dysfunction in 48.1 % (38 patients). High EBC nitrite anion concentration (12.11 ± 1.72 μmol/L) was revealed in asthmatic children compared to control group (3,34 ± 1,58 μmol/L). The results suggest that childhood asthma is associated with morphological and functional abnormalities of pulmonary hemodynamics and endothelium function depending on severity of the disease.
About the Authors
E. A. Starovoytova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
S. N. Ivanov
ГУ НИИ кардиологии ТНЦ СО РАМН
Russian Federation
Russian Federation
L. M. Ogorodova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
References
1. Чучалин А.Г., Огородова Л.М., Петровский Ф.И. и др. Базисная терапия тяжелой бронхиальной астмы у взрослых. Данные национального исследования НАБАТ. Пульмонология 2004; 6: 25–30.
2. Каганов С.Ю. (ред.). Бронхиальная астма у детей. М.: Медицина, 1999.
3. Асриянц И.Э., Копытов Г.А., Харчев А.В. Оценка структурно-функциональных показателей миокарда у детей с бронхиальной астмой. Аллергология 1999; 1: 31–35.
4. Ребров А.П., Кароли Н.А. Эхокардиографические показатели формирования хронического легочного сердца у больных бронхиальной астмой. Клин. мед. 2002; 12: 26–31.
5. Юлдашева И.А. Состояние эндотелия сосудов легких у больных с бронхиальной астмой. Клин. мед. 2004; 5: 36–39.
6. Lipnton H.L., Hautb T.A., Kmrnner W.I. Endothelin produces pulmonary vasoconstriction and systemic vasodilation. J. Appl. Physiol. 1989; 66: 1008–1012.
7. Celemajer D.S. et al. Non-invasive detection in children and adults at risk of atherosclerosis. Lancet 1992; 340 (12): 1111–1115.
8. Палеев Н.Р., Царькова Л.Н., Черейская Н.К. Легочная гипертензия и поражение сердца при хронических неспецифических заболеваниях легких. Кардиология 1988; 12: 58–63.
9. Анаев Э.Х., Чучалин А.Г. Исследование конденсата выдыхаемого воздуха в пульмонологии (обзор зарубежной литературы). Пульмонология 2002; 1: 57–64.
10. Сабиров И.С. Вазодилататоры и гипоксическая легочная гипертония. Вестник КРСУ 2003; 7: 21–26.
11. Gunen H., Hacievliyagil S.S., Kosar F. et all. The role of arterial blood gases, exercise testing, and cardiac examination in asthma. Allergy Asthma Proc. 2006; 27 (1): 45–52.
Review
For citations:
Starovoytova E.A., Ivanov S.N., Ogorodova L.M. Features of pulmonary haemodynamics and endothelium function in children with asthma. PULMONOLOGIYA. 2007;(4):56-59. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-4-56-59
Views:
462
Email this article 