Association between polymorphism at the promotor region of NO-synthase gene and bronchial asthma development
https://doi.org/10.18093/0869-0189-2007-0-4-52-55
Abstract
The purpose of this work was to study NO-synthase gene polymorphic variants in term of asthma occurrence. Clinical and functional characteristics of asthma with regards to different NO-synthase gene polymorphic variants were analyzed in 250 asthmatic children aged 7 to 14 years under the 12-wk standard basic therapy for asthma. We used the typical spectrum of tests for children with asthma and molecular genetic methods. Polymorphism at the promotor region of the NO-synthase gene was found to be associated with phenotype of pathogenic features of asthma and was an important part of inherited predisposition to asthma.
About the Authors
I. V. Petrova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
D. V. Kozyritskaya
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
E. M. Kamaltynova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
L. M. Ogorodova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
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Review
For citations:
Petrova I.V., Kozyritskaya D.V., Kamaltynova E.M., Ogorodova L.M. Association between polymorphism at the promotor region of NO-synthase gene and bronchial asthma development. PULMONOLOGIYA. 2007;(4):52-55. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-4-52-55
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