Genetic markers of bronchial asthma in children with atopic dermatitis
https://doi.org/10.18093/0869-0189-2007-0-4-37-40
Abstract
The aim of the study was to evaluate the usefulness of the -703С/Т polymorphism in IL-5 gene, Q551R polymorphism in IL-4RA gene, and GSTM1 and GSTТ1 gene polymorphism as biological markers of bronchial asthma (BA) in children with atopic dermatitis (AD). We genotyped children with AD (n = 72; mean age, 9.4 ± 0.28 years), children with AD in combination with BA (n = 68; mean age, 7.5 ± 0.7 years) and control subjects (n = 147; mean age, 9.9 ± 0.42 years). We found the associations between BA and the -703С allele of the interleukin-5 (IL-5) gene (OR = 1.73, p = 0.013) and -703СС / 551RR genotype combination (OR = 3.15; p = 0.015) in children with AD; between the 551RR genotype of the IL-4RA gene and atopy (p < 0.05). -703CT / GSТТ1 0/0 genotype combination was found rarer in children with BA than in controls (OR = 0.15; p = 0.049). Thus, -703С/Т allele of the IL-5 gene and -703СС / 551RR genotype combination were associated with BA and could be used as valuable markers of the disease in children with AD, whereas the Q551R polymorphism in the IL-4RA gene was associated with predisposition to atopic disease and could be used for administration of preventive therapy of allergic disorder in early childhood. The -703CT / GSТТ1 0/0 genotype combination can prevent BA occurrence in children with AD.
About the Authors
L. M. Ogorodova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
O. S. Fedorova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
E. Yu. Bragina
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
M. B. Freidin
ГУ НИИ медицинской генетики ТНЦ СО РАМН
Russian Federation
Russian Federation
M. I. Petrovskaya
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
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Review
For citations:
Ogorodova L.M., Fedorova O.S., Bragina E.Yu., Freidin M.B., Petrovskaya M.I. Genetic markers of bronchial asthma in children with atopic dermatitis. PULMONOLOGIYA. 2007;(4):37-40. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-4-37-40
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