Role of soluble adhesion antigens and histocompatibility molecules in development of childhood bronchial asthma
https://doi.org/10.18093/0869-0189-2007-0-4-33-36
Abstract
We determined serum levels of soluble adhesion antigens CD50, CD54, soluble HLA class I molecules, HLA-DR, and relative number of antigenpositive blood mononuclears in asthmatic children. Increased concentrations of soluble CD54 and CD54 antigens and reduction in relative number of CD50+ and CD54+ mononuclear cells were revealed. In children with asthma, the level of serum soluble HLA-DR antigens and relative number of peripheral blood mononuclears were elevated. The worsening of asthma course was accompanied by the increase in CD50, CD54, HLA-DR serum levels. The inverse correlation between the serum levels of soluble CD54 and HLA-DR antigens and FEF50 was revealed.
About the Authors
N. I. Kubisheva
Детская клиническая больница № 27 "Айболит"
Russian Federation
Russian Federation
A. V. Maksimova
Детская клиническая больница № 27 "Айболит"
Russian Federation
Russian Federation
L. B. Postnikova
Военно-медицинский институт ФСБ РФ
Russian Federation
Russian Federation
E. V. Ermolaeva
Детская клиническая больница № 27 "Айболит"
Russian Federation
Russian Federation
L. G. Lazareva
Детская клиническая больница № 27 "Айболит"
Russian Federation
Russian Federation
V. V. Novikov
Нижегородский государственный университет им. Н.И. Лобачевского
Russian Federation
Russian Federation
S. K. Soodaeva
ФГУ НИИ пульмонологии Росздрава
Russian Federation
Russian Federation
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Review
For citations:
Kubisheva N.I., Maksimova A.V., Postnikova L.B., Ermolaeva E.V., Lazareva L.G., Novikov V.V., Soodaeva S.K. Role of soluble adhesion antigens and histocompatibility molecules in development of childhood bronchial asthma. PULMONOLOGIYA. 2007;(4):33-36. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-4-33-36
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