Molecular and genetic mechanisms of eosinophil apoptosis in childhood asthma
https://doi.org/10.18093/0869-0189-2007-0-4-17-22
Abstract
Expression of mRNA apoptosis effectors, antagonists (bcl-2), prodeath protein (bax) and matrix activity of IL-5 in peripheral blood eosinophils were evaluated in children with asthma before and after therapy. Expression of bcl-2 was not revealed in peripheral blood eosinophils of healthy children, however increased expression of IL-5 gene mRNA and increased bcl-2 activity were found in children with asthma. After the course of basis therapy in asthma children, activity of antiapoptotic effectors of bcl-2 family decreased and mRNA expression of proapoptotic factors increased. These modifications were associated with improvement in asthma symptoms and functional parameters.
About the Authors
I. A. Deev
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
A. E. Sazonov
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
L. M. Ogorodova
ГОУ ВПО СибГМУ Росздрава
Russian Federation
Russian Federation
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For citations:
Deev I.A., Sazonov A.E., Ogorodova L.M. Molecular and genetic mechanisms of eosinophil apoptosis in childhood asthma. PULMONOLOGIYA. 2007;(4):17-22. (In Russ.) https://doi.org/10.18093/0869-0189-2007-0-4-17-22
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