Changes in cellular and humoral regulation of immunity in patients with bronchial asthma under treatment with interferon inductor tiloron
https://doi.org/10.18093/0869-0189-2008-0-5-56-59
Abstract
Changes in serum concentrations of interferon-γ (INF-γ), tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), immunoglobulin Е (IgE), С-reactive protein and in clinical status of patients with virus-induced exacerbation of bronchial asthma were studied before and after treatment with basic medications and interferon inductor tiloron. A positive influence of Tiloron on clinical signs and immunologic parameters, such as IL-4, TNF-α, INF-γ, IgE, and С-reactive protein, was found in 95 % of patients with moderate asthma. Thus, serum concentrations of these biomarkers in asthma patients could be used as an index of inflammatory response reflecting severity of the pathology and as an important criterion to choose the individual treatment.
About the Authors
G. N. Shemetova
ГОУ ВПО "Саратовский государственный медицинский университет Росздрава"
Russian Federation
Russian Federation
V. M. Koblov
ГОУ ВПО "Саратовский государственный медицинский университет Росздрава"
Russian Federation
Russian Federation
N. B. Zakharova
ГОУ ВПО "Саратовский государственный медицинский университет Росздрава"
Russian Federation
Russian Federation
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Review
For citations:
Shemetova G.N., Koblov V.M., Zakharova N.B. Changes in cellular and humoral regulation of immunity in patients with bronchial asthma under treatment with interferon inductor tiloron. PULMONOLOGIYA. 2008;(5):56-59. (In Russ.) https://doi.org/10.18093/0869-0189-2008-0-5-56-59
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