Occupational chronic bronchitis: the role of polymorphic variants of antioxidant enzyme genes for susceptibility to the disease
https://doi.org/10.18093/0869-0189-2008-0-2-68-72
Abstract
Distributions of alleles and genotypes of GSTP1Ile105Val and Ala114Val, CAT С(-262)T and C1167T, NQO1 C609T and C465T, GPX1Pro197Leu, GSTM1, GSTT1 polymorphic loci have been studied in patients with occupational chronic bronchitis and in healthy workers. No statistically significant difference was determined in distribution of alleles and genotypes of GSTP1 Ala114Val, CAT С(-262)T and C1167T, NQO1 C609T, GPX1Pro197Leu, GSTM1, GSTT1 polymorphisms between these groups. Polymorphic marker NQO1 C465T was associated with higher risk of occupational chronic bronchitis (OR = 3.68; CI 95 %: 1.68-8.31) suggesting involvement of this gene in development of this pathology.
About the Authors
L. Z. Akhmadishina
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
G. F. Korytina
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
O. V. Kochetova
Институт биохимии и генетики Уфимского научного центра РАН
Russian Federation
Russian Federation
S. R. Mingazova
ФГУН УфНИИ медицины труда и экологии человека Роспотребнадзора г. Уфы
Russian Federation
Russian Federation
A. B. Bakirov
ФГУН УфНИИ медицины труда и экологии человека Роспотребнадзора г. Уфы
Russian Federation
Russian Federation
T. V. Viktorova
Институт биохимии и генетики Уфимского научного центра РАН; Башкирский государственный медицинский университет
Russian Federation
Russian Federation
References
1. Величковский Б.Т. Патогенетическое значение пиковых подъемов среднесуточных концентраций взвешенных частиц в атмосферном воздухе населенных мест. Пульмонология 2000; 3: 10–18.
2. MacNee W. Treatment of stable COPD: antioxidants. Eur. Respir. Rev. 2005; 14 (94): 12–22.
3. Чучалин А.Г. Система оксиданты – антиоксиданты и пути медикаментозной коррекции. Пульмонология 2004; 2: 111–115.
4. Зенков Н.К., Ланкин В.З., Меньщикова Е.Б. Окислительный стресс: Биохимический и патофизиологический аспекты. М.: МАИК "Наука / Интерпериодика"; 2001. 343.
5. Rahman I., Biswas S.K., Kode A. Oxidant and antioxidant balance in the airway diseases. Eur. J. Pharmacol. 2006; 533 (1–3): 222–239.
6. Baranova H., Perriot J., Albuisson E. et al. Peculiarities of the GSTM1 0/0 genotype in French heavy smokers with various types of chronic bronchitis. Hum. Genet.1997; 99: 822–826.
7. Thier R., Lewalter J., Kempkes M. et al. Haemoglobin adducts of acrylonitrile and ethylene oxide in acrylonitrile workers, dependent on polymorphisms of the glutathione transferases GSTT1 and GSTM1. Arch. Toxicol. 1999; 73 (4–5): 197–202.
8. Harries L.W., Stubbins M.J., Forman D. et al. Identification of genetic polymorphisms at the glutathione S-transferase Pi locus and association with susceptibility to bladder, testicular and prostate cancer. Carcinogenesis 1997; 18: 641–644.
9. Ivaschenko T.E., Sideleva O.G., Zelenina L.A. et al. Metabolic gene polymorphisms associated with atopic bronchial asthma. Balkan J. Med. Genet. 2001; 4 (3–4): 23–28.
10. Park S.J., Zhao H., Spitz M.R. et al. An association between NQO1 genetic polymorphism and risk of bladder cancer. Mutat. Res. 2003; 536: 131–137.
11. Sanyal S., Festa F., Sakano S. et al. Polymorphisms in DNA repair and metabolic genes in bladder cancer. Carcinogenesis 2004; 25 (5): 729–734.
12. Forsberg L., de Faire U., Morgenstern R. Low yield of polymorphisms from EST blast searching: analysis of genes related to oxidative stress and verification of the P197L polymorphism in GPX1. Hum Mutat. 1999; 13 (4): 294–300.
13. Forsberg L., Lyrenas L., de Faire U., Morgenstern R. A common functional C-T substitution polymorphism in the promoter region of the human catalase gene influences transcription factor binding, reporter gene transcription and is correlated to blood catalase levels. Free Radic. Biol. Med. 2001; 30 (5): 500–505.
14. Зотова Е.В., Савостьянов К.В., Чистяков Д.А. и др. Поиск ассоциации полиморфных маркеров генов, кодирующих ферменты антиокислительной защиты, с развитием диабетической полинейропатии у больных сахарным диабетом типа 1. Молекул. биол. 2004; 38 (2): 244–249.
15. Swofford L., Selander B. BIOSYS-2: Computer program for the analysis of allelic variation in genetics. Illinois: Department of genetics and development, University of Illinois; 1997.
16. Ye Z., Song H., Higgins J.P.T. et al. Five glutathione s-tr ansferase gene variants in 23,452 cases of lung cancer and 30,397 controls: meta-analysis of 130 studies. PLoS Med. 2006; 3 (4): 0524–0534.
17. Yucesoy B., Johnson V.J., Kashon M.L. et al. Lack of association between antioxidant gene polymorphisms and progressive massive fibrosis in coal miners. Thorax 2005; 60: 429–492.
18. Пай Г.В., Кузьмина Л.П., Ковчан О.В. и др. Генетические маркеры бронхолегочных заболеваний профессионального генеза на примере полиморфных генов глутатион-S-трасферзы М1 и цитохрома Р-4501А1. Мед. генетика 2003; 2 (5): 223–226.
19. Ugenskiene R., Sanak M., Sakalauskas R., Szczeklik A. Genetic polymorphisms in chronic obstructive pulmonary disease. Medicina (Kaunas) 2005; 41 (1):17–22.
20. Chen C., Arjomandi M., Tager I.B. et al. Effects of antioxidant enzyme polymorphisms on ozone-induced lung function changes. Eur Respir J 2007; 30: 677–683.
21. Kinnula V.L. Focus on antioxidant enzymes and antioxidant strategies in smoking related airway disease. Thorax 2005; 60: 693–700.
22. Chistiakov D.A., Zotova E.V., Savost'anov K.V. et al. The 262T>C promoter polymorphism of the catalase gene is associated with diabetic neuropathy in type 1 diabetic Russian patients. Diabetes Metab. 2006; 32 (1): 63–68.
23. Nadif R., Mintz M., Jedlicka A. et al. Association of CAT polymorphisms with catalase activity and exposure to environmental oxidative stimuli. Free Radic. Res. 2005; 39 (12): 1345–1350.
24. Mak J.C.W., Ho S.P., Yu W.C. Polymorphisms and functional activity in superoxide dismutase and catalase genes in smokers with COPD. Eur. Respir. J. 2007; 30: 684–690.
25. Солодилова М.А., Иванов В.П., Полоников А.В. и др. Влияние полиморфизма Pro198Leu гена глутатионпероксидазы 1-го типа на риск развития аллергической бронхиальной астмы у мужчин. Пульмонология 2007; 1: 50–53.
26. Zhang J., Schulz W.A., Li Y. et al. Association of NAD(P)H: quinine oxidoreductase 1 (NQO1) C609T polymorphism with esophageal squamous cell carcinoma in a German Caucasian and a northern Chinese population. Carcinogenesis 2003; 24 (5): 905–909.
27. Sunaga N., Kohno T., Yanagitani N. et al. Contribution of the NQO1 and GSTT1 polymorphisms to lung adenocarcinoma susceptibility. Cancer Epidemiol. Biomarkers Prev. 2002; 11: 730–738.
28. Siegel D., Franklin W.A., Ross D. Immunohistochemical detection of NAD(P)H: quinone oxidoreductase in human lung and lung tumors. Clin. Cancer Res. 1998; 4 (9): 2065–2070.
Review
For citations:
Akhmadishina L.Z., Korytina G.F., Kochetova O.V., Mingazova S.R., Bakirov A.B., Viktorova T.V. Occupational chronic bronchitis: the role of polymorphic variants of antioxidant enzyme genes for susceptibility to the disease. PULMONOLOGIYA. 2008;(2):68-72. (In Russ.) https://doi.org/10.18093/0869-0189-2008-0-2-68-72
Views:
408
Email this article 