Efficiency of nebulizations of ionized silver solution in patients with chronic obstructive lung disease

Abstract

The main problem in preventing exacerbations of chronic obstructive pulmonary disease (COPD) is high cost of medication for regular use and low income of the most patients. Frequent need in antibiotic therapy in COPD patients with concomitant polyvalent allergy, virus infections, antibiotic resistance of pathogens arises some problems in prevention and treatment of COPD. Today there is a great need not only in potent antibiotics but also in additional cheap treatment methods for use in regular basis. These methods should be applicable to other treatments and be active against not only bacterial flora but also other microorganisms. One of such methods meeting these requirements is nebulization of ionized silver solution. Aim of this study was clinical investigation of a new method for prevention of COPD exacerbations using nebulization of ionized silver solution. This double-blind, randomized, placebo-controlled study of long-term therapy with nebulization of ionized silver solution was carried out in 160 patients with mild to moderate COPD. The treatment duration varied from 30 to 180 days. Results showed positive changes in lung function and clinical symptoms. Number and duration of COPD exacerbations associated with acute respiratory virus infections decreased. The optimal daily dose of ionized silver via inhalations was 2 mg.