Efficacy of ambroxol (Lasolvan) in patients with chronic obstructive pulmonary disease
https://doi.org/10.18093/0869-0189-2009-0-1-73-77
Abstract
The aim of this study was to evaluate efficacy of mucolytic drug ambroxol (Lasolvan) as a part of combined treatment of patients with chronic obstructive pulmonary disease (COPD). Fifty-two patients with exacerbation of COPD participated in the study. Bronchoalveolar lavage fluid (BALF) obtained during bronchofiberoscopy was examined for cell differential and immunoglobulin concentration. The latter was found to be reduced. The patients were divided into 2 groups: the main group included 25 patients treated with standard therapy (antibiotics, bronchodilators, glucocorticosteroids) and inhaled ambroxol through a nebulizer; the comparator group included 27 patients with COPD who received standard therapy and placebo (inhaled saline solution). Administration of ambroxol has led to improvement in clinical symptoms and local immunity. In the comparator group, the duration of exacerbation was longer and improvement in the local immunity was insignificant. Therefore, the use of ambroxol as a part of combined therapy of COPD exacerbation could improve the local immunity and contribute to the result of treatment.
About the Authors
U. R. Farkhutdinov
Башкирский государственный медицинский университет; Городская клиническая больница № 21
Russian Federation
Russian Federation
V. V. Petryakov
Городская клиническая больница № 21
Russian Federation
Russian Federation
Sh. U. Farkhutdinov
ВМС УФСБ РФ при РБ
Russian Federation
Russian Federation
References
1. Кокосов А.Н. (ред.). Хронический бронхит и обструктивная болезнь легких. СПб.: Лань; 2002.
2. Чучалин А.Г. (ред.). Респираторная медицина. М.: Гэотар-Медиа; 2007, т. 1.
3. Vandervoorde J., Verbanck S., Gijssels L. et al. Early detection of COPD: a case finding study in general practice. Respir. Med. 2007; 101: 525–530.
4. Langsetmo L., Platt R.W., Ernst P., Bourbeau J. Underreporting exacerbation of chronic obstructive pulmonary disease in a longitudinal cohort. Amer. J. Crit. Care Med. 2008; 177 (4): 396–401.
5. Donaldson G.C., Seemungal T.A.R., Bhowmik A., Wedzicha J.A. Relationship between exacerbation frequency and lung function decline in chronic obstructive pulmonary disease. Thorax 2002; 57 (10): 847–852.
6. Mc Ghan R., Radcliff T., Fish R. et al. Predictors of rehospitalisation and death after a severe exacerbation of COPD. Chest 2007; 132 (6): 1748–1755.
7. Global initiative for chronic obstructive lung disease. Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI / WHO workshop report: updated 2006. Available at: http://www.goldcopd.org/GuidelinesResources.asp?l1=2&l2=0
8. Визель И.Ю., Шмелев Е.И., Визель А.А. Оценка состояния больных хроническим бронхитом и ХОБЛ в период семилетнего наблюдения. Пульмонология 2008; 4: 41–46.
9. Авдеев С.Н., Нуралиева Г.С., Батын С.З. и др. Эффективность комбинированной терапии ингаляционными β2-агонистами и антихолинергическими препаратами при тяжелом обострении хронической обструктивной болезни легких: рандомизированное контролируемое исследование. Пульмонология 2007; 3: 56–65.
10. Hasegawa I., Niisato N., Iwasaki Y., Marunaka Y. Ambroxol-induced modification of ion transport in human airway Calu-3 epithelia. Biochem. Biophys. Res. Commun. 2006; 343 (2): 475–482.
11. Справочник Видаль. Лекарственные препараты в России. М.: Астра-ФармСервис; 2003.
12. Yang B., Yao D.F., Ohuchi M. et al. Ambroxol suppresses influenza-virus proliferation in the mouse airway by increasing antiviral factor levels. Eur. Respir. J. 2002; 19 (5): 952–958.
13. Gibbs B.F., Schmutzler W., Vollrath I.B. Ambroxol inhibits the release of histamine, leukotrienes and cytokines from human leukocytes and mast cells. Inflamm. Res. 1999; 48 (2): 86–93.
14. Paganin F., Bouvet O., Chanez P. et al. Evaluation of the effects of ambroxol on the ofloxacin concentrations in bronchial tissues in COPD patients with infectious exacerbation. Biopharm. Drug Dispos. 1995; 16: 393–401.
15. Stetinova V., Herout V., Kvetina J. In vitro and in vivo antioxidant activity of ambroxol. Clin. Exp. Med. 2004; 4 (3): 152–158.
16. Anthonisen N.R., Manfreda J., Warren C.P.W. et al. Antibiotic therapy in acute exacerbation of chronic obstructive pulmonary disease. Ann. Intern. Med. 1987; 106: 196–204.
17. Герасин В.А. Эндоскопические методы исследования. В кн.: Болезни органов дыхания: руководство для врачей. М.: Медицина; 1989; т. 1: 339–358.
18. Lemoine J.M. Endoskopische befunde der wesentichen bronchopulmonalen krankheiten. Internist 1971; 12: 430–436.
19. Mancini G., Garbonara A., Heremans G. Immunological quantitation of antigens by single radial immunodiffusion. Immunochemestry 1965; 2 (3): 235–254.
20. Куницына Ю.Л., Шмелев Е.И. Противовоспалительная терапия больных при хронической обструктивной болезни легких. Пульмонология 2003; 2: 111–116.
21. Burnett D., Stockley R.A. Serum and sputum alpha-2macroglobulin in patients with chronic obstructive airways disease. Thorax 1981; 36: 512–516.
Review
For citations:
Farkhutdinov U.R., Petryakov V.V., Farkhutdinov Sh.U. Efficacy of ambroxol (Lasolvan) in patients with chronic obstructive pulmonary disease. PULMONOLOGIYA. 2009;(1):73-76. (In Russ.) https://doi.org/10.18093/0869-0189-2009-0-1-73-77
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